Overview

The book is essential for anyone interested in vaccine development, as it highlights the unique advantages of viral vector vaccines in triggering robust, long-lasting immunity and provides an in-depth exploration of the technology and advancements shaping the future of healthcare. Viral vector vaccines have several unique advantages when compared to other vaccine platforms. These powerful vaccines are capable of triggering long-lasting cellular responses, such as cytotoxic T-lymphocytes, that eradicate virus-infected cells. Viral vector-based vaccines use a harmless virus to smuggle the instructions for making antigens from the disease-causing virus into cells, triggering protective immunity against them. In contrast to conventional antigen-containing vaccines, these vaccines use the body’s natural defense system to produce antigens by using a modified virus to deliver genetic code for an antigen. Viral Vectors for Vaccine Delivery provides a comprehensive overview of viral vectors and their applications in vaccine delivery. Its chapters explore various aspects of viral vector technology, from the basic principles of viral vector construction to the latest advancements in gene editing and manufacturing. Readers will find that the book Offers a deep dive into the world of viral vectors, covering their principles, applications, and potential impact on healthcare; Explores how viral vectors are revolutionizing vaccine development, providing a more effective and targeted approach to disease prevention; Discusses the potential of viral vectors to address emerging health challenges and contribute to a healthier world. Audience Research scholars, pharma-process engineers, research scientists, pharmacy students and professionals from the pharmaceutical and biopharmaceutical industry interested in drug discovery, chemical biology, computational chemistry, medicinal chemistry, and bioinformatics

Full Product Details

Author:   Vivek P. Chavda (L. M. College of Pharmacy, Ahmedabad, India) ,  Vasso Apostolopoulos (Victoria University, Melbourne, Australia)
Publisher:   John Wiley & Sons Inc
Imprint:   Wiley-Scrivener
ISBN:  

9781394271535

ISBN 10:   1394271530
Pages:   384
Publication Date:   10 June 2025
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Preface xv 1 Introduction to Viral Vectors 1 Anjali P. Bedse, Suchita P. Dhamane, Shilpa S. Raut, Komal P. Mahajan and Kajal P. Baviskar 1.1 Introduction 2 1.2 Baculovirus Vectors 3 1.3 Adenovirus Vectors 4 1.4 Poxvirus Vectors 6 1.5 Herpes Virus Vectors 8 1.6 Epstein-Barr Virus Vectors 9 1.7 Retrovirus Vectors 10 1.8 Lentivirus Vectors 11 1.9 Adeno-Associated Virus (AAV) 13 1.10 Applications of Viral Vectors 14 1.11 Safety Issues of Viral Vector/Biosafety Challenges 16 1.12 Co nclusion 18 2 Viral Vector Construction 25 Suneetha Vuppu, Toshika Mishra, Shatakshi Mishra, Stany B. and Anushka Das 2.1 Introduction 26 2.2 Applications of Viral Vector 27 2.3 Viral Vectors 29 2.4 Construction of Viral Vectors 42 2.5 Challenges 46 2.6 Advancements in Technology of Viral Vector Construction 49 2.7 Conclusion and Future Prospects 51 3 The Role of Adjuvants in the Application of Viral Vector Vaccines 65 Vivek P. Chavda, Anjali P. Bedse and Shilpa S. Raut 3.1 Introduction 66 3.2 Viral Vector Vaccines: A Powerful Platform 67 3.3 Challenges Associated with Viral Vector Vaccines 69 3.4 The Role of Adjuvants in Overcoming Challenges 72 3.5 Optimizing Adjuvant Design for Viral Vector Vaccines 76 3.6 Conclusion 80 4 Replication-Competent Viral Vectors for Vaccine Delivery 91 Vivek P. Chavda, Pankti C. Balar, Dixa A. Vaghela, Divya Teli, Amit Chaudhari and Shahnaz Alom 4.1 Introduction 92 4.2 Types of Replication-Competent Viral Vectors 93 4.3 Mechanisms of RCVV-Mediated Vaccination 97 4.4 Applications of Replication-Competent Viral Vectors 101 4.5 Conclusion 115 5 Nonreplicating Viral Vectors for Vaccine Delivery 125 Pankti C. Balar and Vivek P. Chavda 5.1 Introduction 126 5.2 Nonreplicating Viral Vectors: Types and Characteristics 127 5.3 Engineering Nonreplicating Viral Vectors for Vaccine Design 132 5.4 Applications of Nonreplicating Viral Vectors in Vaccinology 136 5.5 Optimizing Nonreplicating Viral Vectors for Vaccine Delivery 138 5.6 Challenges and Future Perspectives 141 5.7 Conclusion 143 6 Genetically Modified Viral Vectors for Vaccine Delivery 149 Deepshi Arora, Yugam Taneja, Diksha Gulati, Manish Kumar, Anil Pareek and Rupesh K. Gautam 6.1 Introduction 150 6.2 Genetic Modification of Viral Vectors 153 6.3 Applications of Genetically Modified Viral Vectors 155 6.4 Administration of Vaccines 159 6.5 Immune Response and Protection 161 6.6 Case Studies 163 6.7 Challenges and Future Directions 165 6.8 Conclusion 168 7 DNA- and RNA-Based Viral Vectors 179 Devesh U. Kapoor, Bhumi Bhatt, Dipansu Sahu, Rajiv R. Kakkar, Sonam M. Gandhi and Rupesh K. Gautam 7.1 Introduction to Viral Vectors 180 7.2 Basics of Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) Viruses 180 7.3 DNA-Based Viral Vectors 183 7.4 RNA-Based Viral Vectors 194 7.5 Vector Engineering and Modifications 205 7.6 Preclinical and Clinical Applications 208 7.7 Conclusion 212 8 Manufacturing and Control of Viral-Vector Vaccines: Challenges 221 Vivek P. Chavda, Dixa A. Vaghela, Dhunusmita Barman, Arzoo Newar and Ahmed Nasima 8.1 Introduction 222 8.2 Fundamentals of Viral-Vectored Vaccine Manufacturing 223 8.3 Challenges in Manufacturing Viral-Vectored Vaccines 229 8.4 Quality Control and Assurance in Vaccine Manufacturing 235 8.5 Technological Advances and Innovations in Manufacturing 239 8.6 Supply Chain and Distribution Challenges 244 8.7 Regulatory Hurdles and Compliances 246 8.8 Future Perspectives and Emerging Solutions 248 8.9 Conclusion 248 9 Viral Vectors in Veterinary Vaccine Development 257 Anup Kumar, Pooja Pandita, Harsh Modi, Shahnaz Alom and Vivek P. Chavda 9.1 Introduction 258 9.2 Basics of Viral Vectors 259 9.3 Genetic Engineering of Viral Vectors 262 9.4 Delivery System for Viral Vector Vaccines 265 9.5 Routes of Administration for Viral Vector Vaccines 272 9.6 Comparative Analysis of Different Administration Routes 276 9.7 Applications of Viral Vectors in Veterinary Vaccine Development 280 9.8 Immunology and Immune Response 285 9.9 Safety and Regulatory Considerations 291 9.10 Notable Examples of Viral Vector Vaccines in Veterinary Medicine and Their Impact on Animal Health and Agriculture 295 9.11 Challenges and Future Directions 297 9.12 Conclusion 299 10 Advantages and Challenges of Viral Vector Vaccines 317 Shilpa Dawre, Mahendra Prajapati and Ganesh Shevalkar 10.1 Introduction 317 10.2 Types of Viral Vectors for Vaccine Development 319 10.3 Mechanism of Action of Viral Vectors 324 10.4 Advantages of Viral Vector Vaccines 327 10.5 Challenges of Viral Vector Vaccine 331 10.6 Conclusion 336 11 Commercially Available Viral Vectors and Vaccines 341 Vasso Apostolopoulos, Pankti C. Balar, Arun Kumar Singh and Vivek P. Chavda 11.1 Introduction 342 11.2 Viral Vector-Based Vaccines, Licensed for Humans 342 11.3 Conclusion 350 12 Emerging Viral-Vector Technologies: Future Potential 357 Vasso Apostolopoulos, Pankti C. Balar and Vivek P. Chavda 12.1 Introduction 358 12.2 New Emerging Viral Vectors for Vaccines 358 12.3 Viral Vector Vaccines: What is Good and What is Not So Good 360 12.4 Conclusion 361 References 361 Index 365

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Author Information

Vivek P. Chavda is an assistant professor in the Department of Pharmaceutics and Pharmaceutical Technology, L.M. College of Pharmacy, India with over eight years of experience in biologic research. He has over 250 peer-reviewed national and international publications, including 38 book chapters, seven edited books, ten book chapters, seven patents, and numerous newsletter articles to his credit. His research interests include the development of biologics processes and formulations, medical device development, nano-diagnostics, non-carrier formulations, long-acting parenteral formulations, and nano-vaccines. Vasso Apostolopoulos, PhD, is the Vice-Chancellor’s Distinguished Fellow and Director of the Immunology and Translational Research Group at Victoria University and the Immunology Program Director at the Australian Institute for Musculoskeletal Science. She has over 510 research publications and 22 patents to her credit and has received over 100 awards for her research work. Her research interests include vaccine and drug development for cancer, chronic, infectious, and autoimmune diseases.

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