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Author:   Fredric P. Manfredsson ,  Matthew J. Benskey
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1st ed. 2019
Volume:   1937
Weight:   0.872kg
ISBN:  

9781493990641

ISBN 10:   1493990640
Pages:   328
Publication Date:   01 February 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Preface... Table of Contents... Contributing Authors... Part I Introduction 1. Basic Concepts in Viral Vector-Mediated Gene Therapy Matthew J. Benskey, Ivette M. Sandoval, Kathryn Miller, Rhyomi L. Sellnow, Aysegul Gezer, Nathan C. Kuhn, Roslyn Vashon, and Fredric P. Manfredsson Part II Novel Modes of Gene Therapy (Going Beyond Overexpression and Knockdown) 2. Design and Assembly of CRISPR/Cas9 Lentiviral and rAAV Vectors for Targeted Genome Editing Ivette M. Sandoval, Timothy J. Collier, and Fredric P. Manfredsson 3. Design, Construction, and Application of Transcription Activation-Like Effectors Peter Deng, Sakereh Carter, and Kyle Fink 4. Practical Considerations for the use of DREADD and Other Chemogenetic Receptors to Regulate Neuronal Activity in the Mammalian Brain Patrick Aldrin-Kirk and Thomas Bjoerklund Part III Viral Vectors 5. AAV Production using Baculovirus Expression Vector System Quentin Sandro, Karima Relizani, and Rachid Benchaouir 6. Multimodal Production of Adeno-Associated Virus Ivette M. Sandoval, Nathan M. Kuhn, and Fredric P. Manfredsson 7. Generation of High Titer Pseudotyped Lentiviral Particles Shuang Hu, Mingjie Li, and Ramesh Akkina 8. A Scalable Lentiviral Vector Production and Purification Method using Mustang Q Chromatography and Tangential Flow Filtration Stuart Tinch, Kathy Szcur, William Swaney, Lilith Reeves, and Scott R. Witting 9. Current Use of Adenovirus Vectors and their Purification Methods Ekramy E. Sayedahmed, Rashmi Kumari, and Suresh K. Mittal 10. Construction of Oncolytic Herpes Simplex Virus with Therapeutic Genes of Interest Andranik Kahramanian, Toshihiko Kuroda, and Hiroaki Wakimoto 11. Poxviruses as Gene Therapy Vectors: Generating Poxviral Vectors Expressing Therapeutic Transgenes Steven Conrad and Jia Liu Part IV Viral Vector Delivery 12. AAV Mediated Gene Delivery to the Mouse Liver Sharon C. Cunningham and Ian Alexander 13. Surgical Methods for Inner Ear Gene Delivery in Neonatal Mouse Kevin Isgrig and Wade Chien 14. Gene Transfer to Mouse Kidney In Vivo C. J. Rocca and S. Cherqui 15. Co-Delivery of a Short-Hairpin RNA and a shRNA-Resistant Replacement Gene with Adeno-Associated Virus: An Allele-Independent Strategy for Autosomal Dominant Retinal Disorders Michael T. Massengill, Brianna M. Bowman, Alfred S. Lewin, and Cristian J. Ildefonso 16. Localized Intra-Arterial Gene Delivery using AAV Koji Hosaka, Fredric P. Manfredsson, and Brian Hoh 17. Stable Genetic Modification of Mesenchymal Stromal Cells Using Lentiviral Vectors Francisco Martin, Maria-Tristan-Manzano, Noelia Maldonado, Sabina Sanchez-Hernandez, Karim Benabdellah and Marien Cobo 18. Systemic Delivery of Adeno-Associated Viral Vectors in Mice and Dogs Lakmini P. Wasala, Chady H. Hakim, Yongping Yue, N. Nora Yang, and Donsheng Duan 19. Intrathecal Delivery of AAV Vectors in Cynomolgus Macaques for CNS Gene Therapy and Gene Expression Analysis in Microdissected Motor Neurons Florel Borel, Eric Adams, and Christian Mueller 20. Detailed Method for Intrathecal Delivery of Gene Therapeutics by Direct Lumbar Puncture in Mice Kelsey R. Pfelson, Cristian D. Peterson, Kelley F. Kitto, Lucy Vulchanova, George L. Wilcox, and Carolyn A. Fairbanks 21. Cerebromedullary Cistern Injection of Viral Vectors in Non-Human Primates Lluis Samaranch, Kousaku Ohno, Waldy San Sebastian, and Krystof Bankiewicz

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