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Full Product Details

Author:   Craig E. Cameron (UNC School of Medicine, NC, USA) ,  Jamie J. Arnold (UNC School of Medicine, Chapel Hill, NC, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.700kg
ISBN:  

9780128234686

ISBN 10:   0128234687
Pages:   368
Publication Date:   22 October 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface Craig E. Cameron, Jamie J. Arnold and Laurie S. Kaguni 1. CoV-er all the bases: Structural perspectives of SARS-CoV-2 RNA synthesis Brandon Malone, Seth A. Darst and Elizabeth A. Campbell 2. Mechanisms of inhibition of viral RNA replication by nucleotide analogs Kenneth A. Johnson and Tyler Dangerfield 3. HCV RdRp, sofosbuvir and beyond Joy Y. Feng and Adrian S. Ray 4. Understanding viral replication and transcription using single-molecule techniques Emmanuelle Pitre and Aartjan J.W. te Velthuis 5. In vitro single-molecule manipulation studies of viral DNA replication Rebeca Bocanegra, Ismael Plaza-G.A. and Borja Ibarra 6. Allosteric and dynamic control of RNA-dependent RNA polymerase function and fidelity Dennis S. Winston and David D. Boehr 7. Single-cell analysis for the study of viral inhibitors Mohamad S. Sotoudegan, Jamie J. Arnold and Craig E. Cameron 8. Structural basis of viral RNA-dependent RNA polymerase nucleotide addition cycle in picornaviruses Peng Gong 9. Picornaviral 2C proteins: A unique ATPase family critical in virus replication Pu Chen, Zhijian Li and Sheng Cui 10. Flavivirus enzymes and their inhibitors Ekaterina Knyazhanskaya, Marc C. Morais and Kyung H. Choi 11. Watching the bacterial RNA polymerase transcription reaction by time-dependent soak-trigger-freeze X-Ray crystallography Yeonoh Shin and Katsuhiko S. Murakami 12. Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs Kieran Maheden, Brendan Todd, Calvin J. Gordon, Egor P. Tchesnokov and Matthias Götte

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Author Information

Craig E. Cameron is at UNC School of Medicine, NC, USA Jamie J. Arnold is at UNC School of Medicine, Chapel Hill, NC, USA

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