Overview

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology.

Full Product Details

Author:   Michael G. Katze (Department of Microbiology, University of Washington, Seattle, WA, USA) ,  Marcus J. Korth (Department of Microbiology, University of Washington, Seattle, WA, USA) ,  G. Lynn Law (Department of Microbiology, University of Washington, Seattle, WA, USA) ,  Neal Nathanson (Emeritus Professor, Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Edition:   3rd edition
Dimensions:   Width: 21.60cm , Height: 1.90cm , Length: 27.60cm
Weight:   0.680kg
ISBN:  

9780128009642

ISBN 10:   0128009640
Pages:   366
Publication Date:   04 January 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Viral Pathogenesis: From Basics to Systems Biology 1. The Human Toll of Viral Diseases: Past plagues and pending pandemics Neal Nathanson 2. Historical Roots: The family tree of viral pathogenesis William C. Summers 3. Basic Concepts: A step-by-step guide to viral infection Robert Doms 4. Innate Immunity: Recognizing and responding to foreign invaders—no training needed Christine A. Biron 5. Adaptive Immunity: Neutralizing, eliminating, and remembering for the next time E. John Wherry, David Masopust 6. Aberrant Immunity: The consequences of overreacting or underperforming E. John Wherry, David Masopust 7. Patterns of infection: Unwanted guests—quick visits and extended stays Neal Nathanson and Francisco González-Scarano 8. Viral Oncogenesis: Infections That Can Lead to Cancer Nicholas A. Wallace and Denise A. Galloway 9. HIV and AIDS: Science wrestles with 10,000 nucleotides—points but no pin Guido Silvestri and Emily Cartwright 10. Animal Models: No model is perfect, but many are useful Victoria K. Baxter and Diane E. Griffin 11. Systems Virology: Why Everybody Wants To Measure Everything Marcus J. Korth and G. Lynn Law 12. The Virus-Host Interactome: Knowing the players to understand the game Monika Schneider, Jeffery R. Johnson, Nevan J. Krogan, and Sumit K. Chanda 13. Host Genetics: It’s not just the Virus, Stupid Martin T. Ferris, Mark T. Heise, and Ralph S. Baric 14. Host metabolomics: Yet more ways your health is influenced by fat Priscilla Yang 15. Mathematical Modeling: Solving equations to measure viral diseases – math rules Alan S Perelson 16. Emerging viral diseases: Why we need to worry about bats, camels, and airplanes James W. Le Duc and Neal Nathanson 17. Viral evolution: It’s all about mutations Adi Stern and Raul Andino 18. Viral Epidemiology: Tracking viruses with smartphones and social media Kaitlin Rainwater-Lovett, Isabel Rodriguez-Barraquer and William J. Moss 19. Viral Vaccines: Fighting viruses with viruses Juliet Morrison and Stanley Plotkin 20. Antiviral Therapy Douglas D. Richman and Neal Nathanson 21. Breakthrough: Nobel prize discoveries in viral pathogenesis Neal Nathanson 22. What lies ahead? Scientists look into their crystal balls

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Author Information

Dr. Katze is Professor of Microbiology at the University of Washington and Associate Director for Molecular Sciences and Core Staff Scientist at the Washington National Primate Research Center. He has studied virus-host interactions for 35 years and is an international leader in applying systems biology approaches to infectious disease research. He is an author of over 300 papers and reviews, the majority of which are related to the use of high-throughput and computational methods. He has received the Milstein Award from the International Society of Interferon and Cytokine Research, the Dozor Scholar Award from the Israeli Microbiology Society, and is a Fellow of the American Academy of Microbiology. Dr. Korth is a Senior Research Scientist in the Department of Microbiology at the University of Washington. He specializes in technical and medical writing and the effective communication of scientific concepts in grants, contracts, and the professional literature. He is a member of the American Medical Writers Association and holds a BA in psychology from the University of Wisconsin-Eau Claire, a BS in microbiology and BSMT in medical technology from the University of Montana, and a PhD in microbiology from the University of Washington. His research interests are in the use of systems biology approaches to study viral pathogenesis. Dr. Law is a Senior Research Scientist in the Department of Microbiology at the University of Washington. Her research interests are in the use of high-throughput and computational approaches to study virus-host interactions. She has managed several large programs that utilize different animal models, high-throughput technologies such as microarray and RNS-seq assays, and computational approaches to define the host response to a variety of viruses including influenza, SARS, MERS, and SIV. The overarching goal of these studies is to identify host targets for therapeutic interventions. She holds a BA in chemistry from the University of Colorado and a PhD in biochemistry from Washington State University. Neal Nathanson is emeritus Professor of Microbiology at the University of Pennsylvania. He has spent most of his 50-year career working on the pathogenesis of a wide variety of viral infections, using animal models to investigate the viral and host determinants of disease. He edited the prior two editions of Viral Pathogenesis.

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