Overview

"""...very informative and comprehensive...belongs on the shelf ofevery library and lab providing essential resources for research onvector design or delivery."" -Cancer Biology and Therapy This comprehensive volume presents the most recent advances intarget definition technology and provides a detailed overview onthe rational design of targeted vectors for gene therapy. Atheoretical framework for advanced vector design is provided thatintegrates all of the allied sciences relevant to the study ofvector targeting. The text discusses the basic underlying scienceand then leads to discussions of the various viral vectors andmethods of defining targets. Finally, an expert outlook onpromising therapeutic applications is offered."

Full Product Details

Author:   David T. Curiel (The Gene Therapy Center, The University of Alabama at Birmingham, USA) ,  Joanne T. Douglas (The Gene Therapy Center, The University of Alabama at Birmingham, USA)
Publisher:   John Wiley and Sons Ltd
Imprint:   John Wiley & Sons Inc
Dimensions:   Width: 16.00cm , Height: 3.90cm , Length: 24.50cm
Weight:   1.148kg
ISBN:  

9780471434795

ISBN 10:   0471434795
Pages:   710
Publication Date:   26 August 2002
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Preface. Contributors. PART I: TRANSDUCTIONALLY TARGETED VECTORS--NONVIRAL. Alternative Strategies for Targeted Delivery of NucleicAcid-Liposome Complexes (N. Templeton). Targeted Gene Delivery via Lipidic Vectors (S. Li, et al.). Immunoliposomes: A Targeted Delivery Tool for Cancer Treatment (K.Pirollo, et al.). Receptor-Directed Gene Delivery Using Molecular Conjugates (A.Ziady & P. Davis). PART II: TRANSDUCTIONALLY TARGETED VECTORS--VIRAL. Pseudotyping of Adenoviral Vectors (M. Havenga, et al.). Targeting of Adenoviral Gene Therapy Vectors: The Flexibility ofChemical and Molecular Conjugation (H. Haisma & M. Rots). Genetic Targeting of Adenoviral Vectors (T. Wickham). Strategies to Alter the Tropism of Adenoviral Vectors via GeneticCapsid Modification (D. Curiel). Conjugate-Based Targeting of Adeno-Associated Virus Vectors (S.Ponnazhagan, et al.). Receptor Targeting of Adeno-Associated Virus Vectors (H. Buning, etal.). Mechanisms of Retroviral Particle Maturation and Attachment (A.Miyanohara & T. Friedmann). Targeting Retroviral Vectors Using Molecular Bridges (J.Young). Genetic Targeting of Retroviral Vectors (D. Dingli & S.Russell). Genetic Engineering of Targeted Retroviral Vectors (E. Gordon, etal.). Targeting Measles Virus Entry (A. Hammond, et al.). Targeting of Poliovirus Replicons to Neurons in the Central NervousSystem (C. Morrow, et al.). Generation of Safe, Targetable Sindbis Vectors that Have thePotential for Direct In Vivo Gene Therapy (D. Meruelo, etal.). Redirecting the Tropism of HSV-1 for Gene Therapy Applications (Q.Bai, et al.). Engineering Targeted Bacteriophage as Evolvable Vectors forTherapeutic Gene Delivery (D. Larocca & A. Baird). Targeting Bacteriophage Vectors (I. Saggio). PART III: TRANSCRIPTIONAL TARGETING. Tumor/Tissue Selective Promoters (M. Fernandez & N.Lemoine). Promoter Optimization and Artificial Promoters for TranscriptionalTargeting in Gene Therapy (D. Nettelbeck, et al.). Physiological Targeting (K. Binley). Clostridium-Mediated Transfer of Therapeutic Proteins to SolidTumors (P. Lambin, et al.). PART IV: TARGET DEFINITION. Selection of Peptides on Phage (M. Barry, et al.). Antibody Phage Display Libraries for Use in Therapeutic GeneTargeting (P. Rohrbach & S. Dubel). Single-Chain Fv Fragments from Phage Display Libraries (R.Kontermann). Retroviral Particle Display for Complex Glycosylated andDisulfide-Bonded Protein Domains (S. Kayman). Cell Surface Display and Cytometric Screening for Protein LigandIsolation and Engineering (P. Daugherty). PART V: MONITORING OF TARGETING. Monitoring Gene Therapy By Positron Emission Tomography (H.Herschman, et al.). Index.

Reviews

!provides an excellent up--to--date account of the field!an excellent textbook or addition to the library of a student, researcher, teacher, and any library in general. (ASM News, April 2004) ...provides a very comprehensive picture of the current state of selective targeting of gene therapy vectors...timely, well written, and informative... (Pharmaceutical Research, Vol. 20, No. 12, December 2003) ...very informative and comprehensive...belongs on the shelf of every library and lab providing essential resources for research on vector design or delivery. (Cancer Biology and Therapy)

...provides an excellent up-to-date account of the field...an excellent textbook or addition to the library of a student, researcher, teacher, and any library in general. (ASM News, April 2004) ...provides a very comprehensive picture of the current state of selective targeting of gene therapy vectors...timely, well written, and informative... (Pharmaceutical Research, Vol. 20, No. 12, December 2003) ...very informative and comprehensive...belongs on the shelf of every library and lab providing essential resources for research on vector design or delivery. (Cancer Biology and Therapy)

Author Information

David T. Curiel, M.D. heads the Gene Therapy Center of the University of Alabama at Birmingham. His scientific training includes tenure at the National Institutes of Health in Bethesda, Maryland and at the Pulmonary Branch of the National Heart, Lung, and Blood Institute from 1985-1989, as well as a fellowship in Biotechnology at the National Cancer Institute, Navy Medical Oncology Branch from 1989-1990. Dr. Curiel has been at the University of Alabama at Birmingham since 1993 and is currently Director of the Gene Therapy Center as well as Director of the Division of Human Gene Therapy. He is also Jeanne and Anne Griffin Chair of Women's Cancer Research, and Professor of Experimental Gene Therapy at the Free University of Amsterdam. Joanne T. Douglas, Ph.D. is an Assistant Professor in the Division of Human Gene Therapy at the University of Alabama at Birmingham.

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