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Author:   Pierre Ferrier
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2009 ed.
Volume:   650
Dimensions:   Width: 17.80cm , Height: 1.50cm , Length: 25.40cm
Weight:   0.603kg
ISBN:  

9781441902955

ISBN 10:   1441902953
Pages:   199
Publication Date:   22 June 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Early Steps of V(D)J Rearrangement: Insights from Biochemical Studies of RAG-RSS Complexes.- Regulation of RAG Transposition.- Recent Insights into the Formation of RAG-Induced Chromosomal Translocations.- V(D)J Recombination Deficiencies.- Large-Scale Chromatin Remodeling at the Immunoglobulin Heavy Chain Locus: A Paradigm for Multigene Regulation.- Genetic and Epigenetic Control of V Gene Rearrangement Frequency.- Dynamic Aspects of TCR? Gene Recombination: Qualitative and Quantitative Assessments of the TCR? Chain Repertoire in Man and Mouse.- Germline Transcription: A Key Regulator of Accessibility and Recombination.- Dynamic Regulation of Antigen Receptor Gene Assembly.- Molecular Genetics at the T-Cell Receptor ? Locus: Insights into the Regulation of V(D)J Recombination.- Molecular Pathways and Mechanisms Regulating the Recombination of Immunoglobulin Genes during B-Lymphocyte Development.- Regulation of V(D)J Recombination by E-Protein Transcription Factors.- Temporal and Spatial Regulation of V(D)J Recombination: Interactions of Extrinsic Factors with the RAG Complex.- V(D)J Recombination: Of Mice and Sharks.- Normal and Pathological V(D)J Recombination: Contribution to the Understanding of Human Lymphoid Malignancies.

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Author Information

PIERRE FERRIER is a Principal Investigator and Research Director at the Centre d'Immunologie de Marseille-Luminy (CIML), France. He has also worked as a Director of Marseille-Nice Genopole, a local consortium of more than twenty laboratories aimed at developing high-throughput research techniques in genomics. Main research interests include the analysis of the molecular mechanisms responsible for the control of gene expression and recombination programs during hematopoietic cell development and pathogenesis. He is a member of several national and international scientific organizations including the Institut National de la Sante et de la Recherche Medicale (Inserm), the Agence Nationale de la Recherche (ANR), the Association pour la Recherche sur le Cancer (ARC), the Human Frontier Science Program Organization (HFSPO), and the Universite Virtuelle Medicale de Monaco (UVMM). Pierre Ferrier received his academic degrees from Montpellier (MD) and Marseille (PhD) Universities, France. He was a post-doctoral fellow (1986-90) in the laboratory of Prof. F.W. Alt at the Columbia University College of Physicians and Surgeons, New York, NY, USA.

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