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Author:   R. Day ,  Peter M. Brooks
Publisher:   Birkhauser Verlag AG
Imprint:   Birkhauser Verlag AG
Volume:   v. 44
Weight:   0.620kg
ISBN:  

9783764328696

ISBN 10:   376432869
Pages:   239
Publication Date:   01 July 1993
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

PREFACE. NON-STEROIDAL ANTI-INFLAMMATORY DRUGS. Variability in Response to NSAIDS: What Progress? R.O. DAY Paracetamol in rheumatoid arthritis P. SEIDEMAN Stereochemical Contributions to Variability in Response to NSAIDs Chiral NSAIDS: So What? K.M. WILLIAMS Metabolic chiral inversion of 2-arylpropionates in different tumor cell lines S. MENZEL-SOGLOWEK, G. GEISSLINGER and K. BRUNE (R)-Flurbiprofen: isomeric ballast or active entity of the racemic compound G. GEISSLINGER, S. M-ENZEL-SOGLOWEK and K. BRUNE Further Factors Leading to Variability in Response to NSAIDs Mechanisms of NSAIDs on joint destruction in osteoarthritis K.D. RAINSFORD Pharmacokinetics and phan-nacodynamics of non-steroidal anti-inflammatory drugs in synovial fluid P. NETTER,B. BANNWARTH, F. LAPICQUE, F. DEMOTES-MAINARD, T. SCHCEVERBEKE and P. GILLET Biliary elimination of aspirin after oral and intravenous administration in patients BRUNE, B. NUERNBERG and H.T. SCHNEIDER Mechanisms of gastrointestinal damage by NSAIDs K.D. RAINSFORD TRIALS AND TRIAL DESIGN Variability in individual responses of 532 patients with rheumatoid arthritis to first line and second-line drugs T. PINCUS and L.F. CALLAHAN Towards more informative pilot studies with new anti-rheumatic drugs M.H. LIANG and R.B. BRIGHAM Limitations to standard randomized controlled clinical trials to evaluate combination therapies in rheumatic diseases T. PINCUS COMBINATION THERAPY Combination therapy in rheumatoid arthritis P. M. BROOKS Comparison of clinical effects of bucillamine between additive combination and single administration study in rhewnatoid arthritis M. NOBUNAGA and M. YASUDA DISEASE MODIFYING ANTI-RHEUMATIC DRUGS Mode of action of DMARDs Long-acting antirheumatic drugs induce differentiation of cells of the monocyte -macrophage lineage and alter the expression of cytoldnes and IL-1 receptor antagonist A.C. ALLISON and R.V. WATERS Methotrexate and Antimalarials Methotrexate: New mechanisms and old toxicities D.E. FURST Possible mechanisms of action of antimalarials in rheumatic disease D.J.CUTLER Insights from pharmacokinetic and pharmacodynamic studies of hydroxychloroquine S. TETT, A. MCLACHLAN, R.O. DAY and D.J. CUTLER Toxicity of antimalarial drugs in rheumatoid arthritis R.I. RYNES DMARDs: New and Old Tenidap: A new antiarthritic agent P.M. BROOKS Immunosuppressive and other anti-rheumatic activities of mycophenolate mycophenolate A.C. ALLISON and E.M. EUGUI Antioxidants as anti-rheumatics M.J. PARNHAM and D.R. BLAKE Sulphasalazine in rheumatic diseases M-DOUGADOS Variability in response to D-penicillamine: pharmacokinetic insights D.A. JOYCE Medicinal chemistry of gold G.G. GRAHAM, J.B. ZIEGLER and G.D. CHAMPION Comparative effects of gold on the interactions of transcription factors with DNA M.L. HANDEL, S. SIVERTSEN, C.K.W. WATTS, R.O. DAY and R.L. SUTHERLAND. SUBJECT INDEX.

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