Overview

This book demonstrates the potential of urine as a biomarker resource for early disease detection, covering the related theory, strategies, tools and findings. Biomarker is measurable changes associated with the disease. Blood, as a critical part of the internal environment, is closely monitored and controlled by the body to maintain homeostasis, especially in the early stages of diseases. In contrast, urine, as a form of waste excreted by the body, accumulates early and small changes of the body without homeostatic control. Accordingly, urine can offer an ideal resource for early biomarker discovery. The book discusses exciting preliminary applications of urine biomarkers for diseases affecting major biological systems. It is useful for scientists, clinicians, venture capitalists of related field. In the 2nd edition, most of the chapters are updated and reorganized according to the latest research. Many new chapters have been added to supplement the discussion of this area.  

Full Product Details

Author:   Youhe Gao
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   Second Edition 2025
ISBN:  

9789819678853

ISBN 10:   9819678854
Pages:   427
Publication Date:   06 July 2025
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Not yet available  
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release.

Table of Contents

Chapter 1. Factors beyond science in the development of urine biomarkers.- Chapter 2. Human Urine proteome a powerful source for clinical research.- Chapter 3. Comparison of Urinary Proteomes Among Three Animal Models.- Chapter 4. Urimem, a membrane that preserves urine for largescale biomarker study.- Chapter 5. Posttranslation Modifications of Human Urine.- Chapter 6. Application of Peptide Level and Posttranslational Modifications to Integrative Analyses in Proteomics.- Chapter 7. BiomarkerExtractor a deep learning-based model for text mining of urine biomarkers.- Chapter 8. Why are there proteins in urine.- Chapter 9. Changes in the urine proteome in an acute hypoxic rat model.- Chapter 10. Analysis of the active alterations in the urinary proteome of rats during the immunization process.- Chapter 11.Urine Glucose Levels Are Disordered Before Blood Glucose Level Increase Was Observed in Zucker Diabetic Fatty Rats.- Chapter 12. Comparison of urine proteomes from tumor-bearing mice with those from tumor-resected mice.- Chapter 13. Progress in the application of urine proteomics in cancer biomarker discovery.- Chapter 14. Urine proteome application in neurodegenerative diseases biomarker discovery.- Chapter 15. Urinary Proteome Biomarker Discovery in Autism.- Chapter 16. Progress of urinary proteome research in respiratory diseases.- Chapter 17. Changes of urinary proteome in acute and chronic pulmonary inflammation.- Chapter 18. Changes of urinary proteome in global cerebral ischemia-reperfusion injury.- Chapter 19. Urinary complement factor D is increased in primary malignant hypertension.- Chapter 20. The application of urinary proteomics in early detection of digestive diseases.- Chapter 21. Application of urine proteome in biomarker discovery for cardiovascular diseases.- Chapter 22. Comparison of urinary proteomes among three rat models of abdominal infection bacteria.- Chapter 23. Serial Changes of Urinary Proteome in Animal Models of Renal Diseases.- Chapter 24. Dynamic urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury.- Chapter 25. Using one–to–many urine proteome comparisons to provide clues for fever of unknown origin.- Chapter 26. Exploring the overall effects of two traditional Chinese medicines on the body by urinary proteome.- Chapter 27. Effects of extrinsic factors on the urinary proteome.- Chapter 28. Take a deep breath.- Chapter 29. Tears: Potential Window for Monitoring Systemic Conditions.- Chapter 30. Changes of urine protiens in the rat e-cigarette model.- Chapter 31. Changes in the urinary proteome of rats after short-term intake of magnesium L-threonate(MgT).

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Author Information

Dr. Youhe Gao is a Professor at the College of Life Sciences, Beijing Normal University. Further, he is the chair of Urine Proteome Initiative of Human Proteome Project (HPP) Human Proteome Organization (HUPO). Prof. Gao is the winner of the National Science Fund for Distinguished Young Scholars Award and the New Century National Hundred, Thousand and Ten Thousand Talent Project. His research chiefly focuses on urinary biomarker, an area in which he has published more than 130 articles.  

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