Understanding Cancer from a Systems Biology Point of View: From Observation to Theory and Back
Author:   Irina Kareva (Tufts Medical Center, Boston, MA USA)
Publisher:   Elsevier Science Publishing Co Inc
ISBN:  

9780128136737


Pages:   118
Publication Date:   08 February 2018
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Our Price $396.00 Quantity:  
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Understanding Cancer from a Systems Biology Point of View: From Observation to Theory and Back


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Author:   Irina Kareva (Tufts Medical Center, Boston, MA USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.140kg
ISBN:  

9780128136737


ISBN 10:   0128136731
Pages:   118
Publication Date:   08 February 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Introduction 2. Tumor dormancy 3. Cancer immunoediting: a process driven by metabolic competition as a predator-prey-shared resource type model 4. Escape from tumor dormancy and time to angiogenic switch as mitigated by tumor- induced stimulation of stroma 5. Angiogenesis regulators as a possible key to accelerated growth of secondary tumors following primary tumor resection 6. A combination of immune checkpoint inhibition with metronomic chemotherapy as a way of targeting therapy-resistant cancer cells 7. Summary and conclusions

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Author Information

Dr. Irina Kareva is a theoretical biologist, and the primary focus of her research involves using mathematical modeling to study cancer as an evolving ecosystem within the human body, where heterogeneous populations of cancer cells compete for limited resources (i.e., oxygen and glucose), cooperate with each other to fight off predators (the immune system), and disperse and migrate (metastases). In 2017 Dr. Kareva gave a TED talk on using mathematical modeling for biological research. Dr. Kareva's book Understanding cancer from a systems biology point of view: from observation to theory and back was published by Elsevier in 2018. Dr. Kareva is a Senior Scientist in Simulation and Modeling at EMD Serono, Merck KGaA, where she develops quantitative systems pharmacology (QSP) models to help understand and predict dynamics of new therapeutics.

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