Overview

The estimate for the number of existing microbial species is 105 -- 106, but only some thousands have been isolated in pure culture and described. The principal reason for this gigantic disparity is that, mysteriously, over 99% of all environmental microorganisms refuse to grow in the laboratory. The phenomenon of microbial uncultivability has been recognized as one of the main challenges for basic and applied microbiology and finding a way to access this uncultivated microbial majority may change many aspects of biology and biotechnology as we know them today. This volume presents the discovery of the phenomenon, the current hypotheses on its molecular nature, state-of-the-art approaches of ""outsmarting"" the uncultivated microorganisms and the principal applications of the new insights into medicine and biotechnology. Hopefully, it will be the key to the hidden universe of uncultivated microorganisms, their unparallel diversity and enormous applied potential.

Full Product Details

Author:   Slava S. Epstein
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2009 ed.
Volume:   10
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   0.541kg
ISBN:  

9783540854647

ISBN 10:   3540854649
Pages:   208
Publication Date:   23 July 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Viable but Not Cultivable Bacteria.- General Model of Microbial Uncultivability.- Statistical Estimation of Uncultivated Microbial Diversity.- Detection and Characterization of Uncultivated Microorganisms Using Microarrays.- Persisters, Biofilms, and the Problem of Cultivability.- Metagenomics and Antibiotic Discovery from Uncultivated Bacteria.- Taking the Concept to the Limit: Uncultivable Bacteria and Astrobiology.- Single Cell Whole Genome Amplification of Uncultivated Organisms.- Physiological and Ecological Adaptations of Slow-Growing, Heterotrophic Microbes and Consequences for Cultivation.- Characterizing Microbial Population Structures through Massively Parallel Sequencing.- The Seabed as Natural Laboratory: Lessons From Uncultivated Methanotrophs.

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