Overview

This book provides up-to-date information on the mechanisms of protein degradation and highlights the significance of protein quality control for cellular physiology and pathology specifically in CNS neurodegenerative diseases. Chapters cover cellular bioenergetics, environmental factors, protein load, and their respective roles in the pathogenesis and progression of diseases. Additionally, the book addresses the array of experimental tools (models) available for studying disease etiology, progression, and therapeutics, offering a balanced discussion of their advantages and disadvantages. It provides insights into the effects of both sporadic and genetic models in investigating disease mechanisms, with a perspective on experimental model systems. The book is relevant for scientists and researchers in the fields of neuroscience, cellular signaling, protein, and systems biology. It is also valuable for clinicians interested in both basic and translational research in the field of central nervous system (CNS) neurodegenerative diseases.

Full Product Details

Author:   Sarika Singh
Publisher:   Springer Verlag, Singapore
Imprint:   Springer Verlag, Singapore
ISBN:  

9789819560981

ISBN 10:   9819560985
Pages:   378
Publication Date:   24 February 2026
Audience:   Professional and scholarly ,  College/higher education ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Not yet available  
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Table of Contents

Section I: Introduction to Ubiquitin Proteasome System (UPS).- Chapter 1: Ubiquitin Proteasome System (UPS): Role in Cellular Physiology.- Chapter 2: Ubiquitin Proteasome System (UPS) and Molecular Chaperones.- Chapter 3: Ubiquitin Proteasome System (UPS) and Energy Bioenergetics.- Section II: Signaling Mechanisms in Ubiquitin Proteasome System (UPS).- Chapter 4: Protein Homeostasis and Ubiquitin Proteasome System (UPS).- Chapter 5: Neuroinflammation and Ubiquitin Proteasome System (UPS).- Chapter 6: Endoplasmic Reticulum and Ubiquitin Proteasome System (UPS).- Chapter 7: Triggers of Ubiquitin Proteasome System (UPS): Disease Aspects.- Chapter 8: Ubiquitin Signaling in Central Nervous System (CNS) Neurodegenerative Diseases.- Chapter 9: E3 Ubiquitin Ligases in Central Nervous System (CNS) Neurodegenerative Diseases.- Chapter 10: Deubiquitinating Enzymes in Central Nervous System (CNS) Neurodegenerative Disease.- Chapter 11: Proteasome Machinery in Neurodegenerative Signaling.- Section III: Therapeutic Options for Ubiquitin Proteasome System (UPS).- Chapter 12: Targeting Ubiquitin Proteasome System (UPS) by Natural Products.- Chapter 13: Inhibitors of Protein Aggregates.- Chapter 14: HDAC Inhibitors on Protein Quality Control System.- Section IV: Experimental Tools for Ubiquitin Proteasome System (UPS).- Chapter 15: Animal Models of Disease.- Chapter 16: Pros and Cons of Sporadic Versus Genetic Models of Diseases.

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Author Information

Dr. Sarika Singh completed her master's in biochemistry and a Ph.D. in the role of nitric oxide in the pathology of Parkinson’s disease from Lucknow University, Lucknow, India. She is working as a senior principal scientist and Professor at the Academy of Scientific and Innovative Research (AcSIR) at CSIR-Central Drug Research Institute in Lucknow, Uttar Pradesh, India. Dr. Singh’s major research focuses on identifying diagnostic markers and novel signaling factors participate in neurodegeneration. She is actively involved in search for novel therapeutic molecule for management of Alzheimer’s and Parkinson’s diseases. Her exploratory studies target the contributions of bioenergetics and unfolded protein responses in neurodegenerative conditions. She has published over 85 articles in peer-reviewed national and international journals and is an editorial board member and reviewer for various journals. Dr. Singh is a lifetime member of the Indian Academy of Neurosciences and the National Academy of Sciences.

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