Overview

Type 1 diabetes, sometimes called juvenile-onset or insulin-dependent diabetes, is an autoimmune condition in which the β cells in the pancreas that produce insulin are destroyed by the body's immune system. The disease affects millions of individuals, but for more than 100 years, diet and insulin injections were the only effective treatment. Recent discoveries, however, have led to new therapies and finally the promise of a cure. Written and edited by experts in the field, this new collection from Cold Spring Harbor Perspectives in Medicine discusses exciting research that has increased our understanding of the mechanisms underlying development of type 1 diabetes. The contributors discuss immunological, genetic and environmental contributions to disease susceptibility, the part β cells play, and how interactions with the immune system drive pathogenesis. They examine the failure of immune tolerance, the role of T cells, specific features of autoimmunity, and the importance of neoantigens in the disease, as well as the important question of whether it is β cells or the immune system that becomes dysfunctional first. In addition, the volume reviews the incredible progress in development of treatments for type 1 diabetes, including novel therapies that rebalance the immune system and pancreatic islet-cell transplantation. The long journey to approval of teplizumab to treat individuals at high risk is also covered. The new book will therefore be of interest to all endocrinologists and immunologists seeking to learn more about this disease but also those working in drug development.

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9781621825074

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