Overview

Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases, extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis - these include vascular endothelial growth factor, the basic fibroblast growth factor family, transforming growth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumour microvessel density and the therapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.

Full Product Details

Author:   Roy Bicknell (Institute of Molecular Medicine, Oxford) ,  Claire E. Lewis (University of Sheffield Medical School) ,  Napoleone Ferrara (Genentech Inc., South San Francisco) ,  Napoleone Ferrara (Genentech Inc, South San Francisco, USA)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 19.80cm , Height: 2.80cm , Length: 25.50cm
Weight:   1.163kg
ISBN:  

9780198549376

ISBN 10:   0198549377
Pages:   396
Publication Date:   03 July 1997
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

1: Bicknell, Lewis & Ferrara: Introduction 2: Fan & Polverini: In Vivo Models of Angiogenesis 3: Bicknell: Mechanistic Studies of Tumour Angiogenesis 4: Gasparini: Prognostic and Predictive Value of Intra-tumoral Microvessel Density in Human Solid Tumours 5: Jain: Vascular and Interstitial Physiology of Tumours: Role in Cancer Detection & Treatment 6: Chaplin, Trotter, & Dougherty: Microregional Tumour Blood Flow: Heterogeneity & Therapeutic Significance 7: Keshet, Stein, Neeman: Mechanisms of Stress-Induced Angiogenesis in Tumours 8: Leek, Lewis, & Harris: The role of Macrophages in Tumour Angiogenesis 9: Rastinejad & Bouck: Oncogenes and Tumour Suppressor Genes in the Regulation of Angiogenesis 10: Lewis & Balkwill: The role of cytokines in angiogenesis 11: Bikfalvi, Klein, & Pintucci: The Role of Proteases in Angiogenesis 12: Vlodavsky, Miao, Ishai-Michaeli, Benezra, Levy, Bar-Shavit & Peretz: Involvement of the Extracellular Matrix, Heparan Sulfate Proteoglycans and Heparan Sulfate Degrading Enzymes in Angiogenesis and Metastasis 13: Rooney, Kumar, Ponting & Kumar: The Role of Collagens and Proteoglycans in Tumour Angiogenesis 14: Hisrt & Flitney: The Physiological Importance and Therapeutic Potential of Nitric Oxide in the Tumour-associated Vasculature 15: Bobik, Agrotis & Little: Vascular Derived Growth Factors: Potential Role in the Development of the Tumour Vasculature 16: Ferrara: The Role of Vascular Endothelial Growth Factor in the Regulation of Blood Vessel Growth 17: Christofori: The Role of Fibroblast Growth Factors in Tumour Progression and Angiogenesis 18: Madri & Sankar: The Biphasic Effects of Transforming Growth Factor in Angiogenesis 19: Moghaddam, Choudhuri & Bicknell: Thymidine phosphorylase/platelet-derived endothelial cell growth factor an angiogenc enzyme 20: Fajardo & Allison: Tumor Necrosis Factor and Angiogenesis 21: Schulte & Wellstein: Pleiotrophin and Related Molecules 22: Spisni & Tomasi: The Involvement of prostanoids in angiogenesis 23: Bicknell & Holmgren: The Inhibition of tumour angiogenesis 24: Pepper, Tacchini-Cottier, Sabapathy, Montesano & Wagner: Endothelial Cells Transformed by Polyomavirus Middle-T Oncogene: A Model for Haemangiomas and Other Vascular Tumours 25: Young & Laskey: Development of the Embryonic Vascular System 26: Derbyshire & Thorpe: Targeting the Tumour Endothelium Using Specific Antibodies 27: Bicknell: Vascular Targeting of anti-cancer gene therapy

Reviews

'...a timely book about an area that is rapidly gaining in popularity...this contribution will be most useful for the researchers in the field, in particular for scientists new to angiogenesis who will benefit from this extensive and thorough introduction. The book will also function well as a dictionary for people working in related areas...this is an extensive, well written and comprehensive book.' Trends in Cell Biology (Vol.8) October 1998. 'This is an interesting book...' Cellular & Molecular Biology, June vol.44/No.4, 1998.

Author Information

Dr Roy Bicknell, Imperial Cancer Research Fund, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxon OX3 9DU, Tel (1865) 222421, Fax (1865) 222431, email: bicknelr.@icrf.icnet.uk; Dr C E Lewis, Senior Lecturer, Department of Pathology, University of Sheffield Medical School, Royal Hallamshire Hospital, Sheffield S10 2JF, Tel (0114) 271 2903, Fax (0114) 278 0059 Dr N Ferrara, Department of Cardiovascular Research, Grenentech Inc, South San Francisco, California, USA,

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