Overview

Leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to discover and isolate novel tumor suppressor genes and their targets. For both volumes: Leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to discover and isolate novel tumor suppressor genes and their targets. A second volume of this two-volume set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medical Applications, shows how to explore the cell biology and biochemical function of such encoded proteins, to study its physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer.

Full Product Details

Author:   Wafik S. El-Deiry
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2nd Revised edition
Volume:   222
Dimensions:   Width: 17.80cm , Height: 2.80cm , Length: 25.40cm
Weight:   1.142kg
ISBN:  

9780896039865

ISBN 10:   0896039862
Pages:   520
Publication Date:   03 March 2003
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Part I. Known Tumor Suppressor Genes and Pathways Growth Control by the Retinoblastoma Gene Family Marco G. Paggi, Armando Felsani, and Antonio Giordano The APC Tumor Suppressor Pathway Patrice J. Morin and Ashani T. Weeraratna Hereditary Breast and Ovarian Cancer Genes Ralph Scully and Nadine Puget Hereditary Colon Cancer Genes William M. Grady and Sanford D. Markowitz Patched, Hedgehog, and Skin Cancer Anthony G. Quinn and Ervin Epstein, Jr. Tumor Suppressor Genes in Lung Cancer Arvind K. Virmani and Adi F. Gazda TP53, hChk2, and the Li-Fraumeni Syndrome Jenny Varley Genetic Alterations in Esophageal Cancer Jun-ichi Okano, Lorraine Snyder, and Anil K. Rustgi PTEN and Cancer Ramon Parsons and Laura Simpson VHL and Kidney Cancer Michael Ohh and William G. Kaelin, Jr. p16INK4A and Familial Melanoma Kapaettu Satyamoorthy and Meenhard Herlyn The INK4a/ARF Locus and Human Cancer Greg H. Enders Progression Model of Prostate Cancer Teresa Acosta Almeida and Nickolas Papadopoulos Neurofibromatosis Type 1 Margaret E. McLaughlin and Tyler Jacks Wilms' Tumor as a Model for Cancer Biology Andrew P. Feinberg and Bryan R. G. Williams Inadequate 'Caretaker' Gene Function and Human Cancer Development Theodore L. DeWeese and William G. Nelson Regulation of Tumor Suppressor Genes by Oncogenes Paul Dent, Liang Qiao, Donna Gilfor, Michael Birrer, Steven Grant, and Paul B. Fisher Part II. Identification of Tumor Suppressor Genes Determination of Cancer Allelotype Jennifer J. Ascano and Steven M. Powell Epidemiologic Approaches to the Identification of Cancer Predisposition Genes Timothy R. Rebbeck Characterization of Translocations in Human Cancer Keri Fairand Michelle M. Le Beau Positional Approaches to Cancer Genetics Gavin P. Robertson, Linda Sargent, and Mark A. Nelson Hybrid Capture of Putative Tumor Suppressor Genes Bryan L. Betz and Bernard E. Weissman Approaches to Proteomic Analysis of Human Tumors Mamoun Ahram and Michael R. Emmert-Buck Representational Difference Analysis of Gene Expression James M. Bugni and Norman R. Drinkwater Antisense Libraries to Isolate Tumor Suppressor Genes Adi Kimchi Genetic Suppressor Elements in the Characterization and Identification of Tumor Suppressor Genes Igor B. Roninson and Andrei V. Gudkov Cross-linking Subtractive Hybridization to Identify Tumor Suppressor Genes Gen Sheng Wu Suppression Subtractive Hybridization for Identification and Functional Analysis of Tumor Suppressor Genes Iuri D. Louro, Evans C. Bailey, and J. Michael Ruppert SAGE as a Strategy to Isolate Cancer-Related Genes Kathy Boon and Gregory J. Riggins Differential Display Techniques to Identify Tumor Suppressor Gene Pathways Siham Biade and Maureen E. Murphy Detection of Mismatch Repair Gene Expression in Urologic Malignancies Fredrick S. Leach Index

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