Overview
Biomarkers are molecular indicators of a biological status and, as biochemical species, can be interrogated to evaluate disease status and therapeutic interventions. Biomarkers may be detectable in the blood, other body fluids, or tissues. The expectation is that the level of an informative biomarker is related to the specific type of disease present in the body. Hence, disease-relevant biomarkers can be used to measure the presence, progress, or intensity of disease. Through a variety of mechanisms, cancer cells provide the biomarker material for their own detection. Tumor biomarkers include cancer-specific mutations or changes in gene expression, both of which can result in aberrant protein expression. These variant or abundant proteins can be detectable in the circulation as the free proteins or as novel autoantibodies to those proteins, the latter indicating that the immune system can provide an exquisitely sensitive sensor of disease. Because cancer cells shed DNA in the circu- tion, an event rarely seen in healthy individuals, tumor-specific genetic changes, such as promoter methylation or gene mutations, are detectable in DNA prepared from plasma or other body fluids. Cancer-related biochemical changes often effect measurable me- bolic variations within a cell or organism. In addition, these biochemical changes result in posttranslational modification of proteins via glycosylation or phosphorylation providing a plethora of opportunity for biomarker discovery.
Full Product Details
Author: Michael A. Tainsky
Publisher: Humana Press Inc.
Imprint: Humana Press Inc.
Edition: Softcover reprint of hardcover 1st ed. 2009
Volume: 520
Dimensions:
Width: 19.30cm
, Height: 2.00cm
, Length: 26.00cm
Weight: 0.877kg
ISBN: 9781617379154
ISBN 10: 1617379158
Pages: 332
Publication Date: 20 January 2011
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Paperback
Publisher's Status: Active
Availability: Manufactured on demand
We will order this item for you from a manufactured on demand supplier.
Reviews
From the reviews: This well-illustrated book is an excellent resource on nucleic acid and protein-based technologies and metabolic profiling by analytic means or mass spectroscopy as well as for study designs for tumor biomarker discovery and validation. The audience includes both researchers interested in the identification and development of new tumor biomarkers and clinicians who need to be familiar with these new technologies in order to ... treat cancer patients. In addition to researchers and clinicians, students interested in tumor biomarkers will find this book extremely useful. (Omer Iqbal, Doody's Review Service, January, 2010)
From the reviews: “This well-illustrated book is an excellent resource on nucleic acid and protein-based technologies and metabolic profiling by analytic means or mass spectroscopy as well as for study designs for tumor biomarker discovery and validation. The audience includes both researchers interested in the identification and development of new tumor biomarkers and clinicians who need to be familiar with these new technologies in order to … treat cancer patients. In addition to researchers and clinicians, students interested in tumor biomarkers will find this book extremely useful.” (Omer Iqbal, Doody’s Review Service, January, 2010)
From the reviews: This well-illustrated book is an excellent resource on nucleic acid and protein-based technologies and metabolic profiling by analytic means or mass spectroscopy as well as for study designs for tumor biomarker discovery and validation. The audience includes both researchers interested in the identification and development of new tumor biomarkers and clinicians who need to be familiar with these new technologies in order to ! treat cancer patients. In addition to researchers and clinicians, students interested in tumor biomarkers will find this book extremely useful. (Omer Iqbal, Doody's Review Service, January, 2010)
