Overview

This volume is not intended as review of the large literature on tumor antigenicity and efforts at tumor immunotherapy. Its pur­ pose, rather, is to present discursively an outline of the likely approaches to immunological intervention in neoplastic diseases which present themselves today, in light ofthe probable antigenic properties of cancer cells. References are cited only selectively, in illustration of some of the major considerations to which allusion is made and of some of the supportive evidence. No attempt is made at inclusiveness in the citation of concepts and fmdings. If undue emphasis appears to be given to some aspects of the litera­ ture and only sparse documentation to others, the grounds do not lie necessarily with a critical estimation of the extent or quality of reported work, but rather with the bias of the writer who consi­ ders stress on some facets of the field more appropriate than on others for elaboration of his arguments. The references brought in support of a given point are often intentionally varied,including both reports of original work and reviews, very recent observa­ tions and contributions that gave initial impetus to investigations, in an attempt to exemplify the pertinent literature; and reference is made both to data presented and to concepts advanced.

Full Product Details

Author:   David W. Weiss
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1980
Volume:   89
Dimensions:   Width: 17.00cm , Height: 0.50cm , Length: 24.40cm
Weight:   0.189kg
ISBN:  

9783642674990

ISBN 10:   3642674992
Pages:   86
Publication Date:   18 October 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1 Tumor-Associated Antigenicity and Host Responsiveness: Basic Questions and Considerations.- 2 Tumor Etiology and Antigenicity.- 2.1 Tumors Known to be Induced by Viruses.- 2.2 Tumors Known to be Induced by Chemical Agents and by Other Carcinogenic Stimuli.- 2.3 “Spontaneous” Tumors, with No Obvious Viral Etiology (Animal und Human).- 3 Approaches to Immunotherapy.- 3.1 Active “Nonspecific Immunogherapy” with Immunomodulating Agents.- 3.2 Active Specific Immunization with Tumor Cell Antigens.- 3.3 Passive and Adoptive Immunological Intervention.- 4 Concluding Remarks.- 4.1 Immune Surveillance and Immunological Intervention: Hypothesis and Empiricism.- 4.2 Key Aspects of the Approaches to Tumor Immunotherapy.- 4.3 Goals and Expectations.- 4.4 Experimental Perspectives.- 4.5 Immunological Capacity, Immunological Monitoring, and Susceptibility to Neoplastic Disease.- 4.6 Immunological and Nonimmunological Resistance to Progressive Neoplasia.- 4.7 Coda.- 5 Notes added in Press.- Acknowledgements.- References.

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