Overview

Preface Tumor development and progression occur as a result of cumulative acquisition of genetic alterations affecting oncogenes and tumor suppressor genes. As a consequence of these alterations the arising tumor gains some fatal properties such as increased cell proliferation and decreased apoptosis, resulting in a net accumulation of tra- formed cells. Once a critical volume is achieved, lack of oxygen and nutrients limits further growth. To overcome this obstacle, the tumor cells initiate a program focused on the formation of new blood vessels within the host tissue. This process is termed tumor angiogenesis and contributes to the progression of most solid tumors and the formation of metastases. Since its discovery more than 30 years ago by Dr. Judah Folkman, tumor angiog- esis has been proposed as an ideal target for novel tumor therapies. Today the first anti-angiogenic compounds are available for the treatment of patients but their s- cess in the clinic is rather limited when given as monotherapies. This is in contrast to many preclinical results which revealed a much higher efficacy of these therapeutics in appropriate animal models. The reasons for this discrepancy are manifold, one being the existence of more than one angiogenic signaling system capable of driving tumor angiogenesis. Therefore it is no surprise that the inhibition of just one system is not sufficient to block the formation of new blood vessels in patients.

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9783662517987

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Reviews

From the reviews: The chapters in Tumor Angiogenesis are divided into four sections ... . Tumor Angiogenesis is an outstanding overview of the basic science and translational aspects of angiogenesis. ... To fully capitalize on antiangiogenic therapy, we must continue to have an open dialogue between basic scientists and clinical investigators. This book will serve that purpose, not only for graduate students and new investigators in the field, but also for experienced investigators. (Lee M. Ellis, The New England Journal of Medicine, May, 2008)

From the reviews: The chapters in Tumor Angiogenesis are divided into four sections ... . Tumor Angiogenesis is an outstanding overview of the basic science and translational aspects of angiogenesis. ... To fully capitalize on antiangiogenic therapy, we must continue to have an open dialogue between basic scientists and clinical investigators. This book will serve that purpose, not only for graduate students and new investigators in the field, but also for experienced investigators. (Lee M. Ellis, The New England Journal of Medicine, May, 2008)

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