Tubulin-Binding Agents: Synthetic, Structural and Mechanistic Insights
Author:   Teresa Carlomagno
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Edition:   2009 ed.
Volume:   286
ISBN:  

9783642435942


Pages:   331
Publication Date:   06 November 2014
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Tubulin-Binding Agents: Synthetic, Structural and Mechanistic Insights


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reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a “time-resolved” picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.

Full Product Details

Author:   Teresa Carlomagno
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2009 ed.
Volume:   286
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.528kg
ISBN:  

9783642435942


ISBN 10:   3642435947
Pages:   331
Publication Date:   06 November 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Macrolide-Based Microtubule-Stabilizing Agents – Chemistry and Structure–Activity Relationships.- The Chemical Synthesis of Discodermolide.- The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels.- The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR.- The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography.- Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin.- Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents.

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