Overview

Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention.  TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field.  Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the genitourinary tract.  Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.   Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.

Full Product Details

Author:   Arpad Szallasi ,  Tamás Bíró
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2012 ed.
Dimensions:   Width: 17.80cm , Height: 3.00cm , Length: 25.40cm
Weight:   1.056kg
ISBN:  

9781627030762

ISBN 10:   162703076
Pages:   446
Publication Date:   20 September 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Introduction to TRPs: A Quest for Novel Drug Targets.- TRP-Mediated Cytoskeletal Reorganization: Implications for Disease and Drug Development.- TRPA1 in Drug Discovery.- Canonical Transient Receptor Potential Channel (TRPC) Expression, Regulation, and Function in Vascular and Airway Diseases.- TRPM2 Function and Potential as a Drug Target.- The Ca2+-Activated Monovalent Cation Selective Channels TRPM4 and TRPM5.- The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis.- TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation.- TRPML Channels in Function, Disease, and Prospective Therapies.- The TRPP Signalling Module: TRPP2/Polycystin 1 and TRPP2/PKD1L1.- TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities.- Nociceptive and Non-Nociceptive Roles of TRPV3 and Its “Druggability”.- TRPV4 and Drug Discovery.- TRP Expression and Function in the Lung Airways.- Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells.- Endotoxin-Induced Airway Inflammation and Asthma Models.- Enhanced Cough, Animal Models.- Capsaicin Inhalation Test in Man.- TRP Channels in the Genitourinary (GU) Tract.- Animal Models of Cystitis.- Overactive Bladder Models.

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