Overview

This publication provides an assessment of the carcinogenic hazards associated with exposure to seven chlorinated solvents, including trichloroethylene, tetrachloroethylene, and their metabolites (dichloroacetic acid, trichloroacetic acid, and chloral hydrate). All these agents were previously assessed by IARC Working Groups more than 10 years ago, and new epidemiological and mechanistic evidence has been considered in this reevaluation. Trichloroethylene has been used in several industries, such as manufacture and repair of aircraft and automobiles, and in screw-cutting, while tetrachloroethylene is widely used in dry-cleaning and as a feedstock for the production of chlorinated chemicals.

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The International Agency for Research on Cancer (IARC) is part of the World Health Organization. IARC's mission is to coordinate and conduct research on the causes of human cancer, the mechanisms of carcinogenesis, and to develop scientific strategies for cancer control. The Agency is involved in both epidemiological and laboratory research and disseminates scientific information through publications, meetings, courses, and fellowships.

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