Overview

Leading clinicians and scientists in solid organ transplantation review the current status of the field and describe cutting-edge techniques for detecting the immune response to the allografted organ. The authors present the latest techniques for HLA typing, detecting HLA antibodies, and monitoring T-cell response, and examine more specialized methods utilizing proteomics, laser dissection microscopy, and real-time polymerase chain reaction. The area of tolerance induction and reprogramming of the immune system is also covered, along with a discussion of up-to-date methods of organ preservation, of today's optimal immunosuppressive drug regimens, as well as the difficulty of mimicking chronic rejection in experimental models. Introductory chapters provide a theoretical update on current practices in renal, liver, islet, and lung transplantation and on the pathways of antigen presentation and chronic rejection.

Full Product Details

Author:   Philip Hornick ,  Marlene Rose
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2006 ed.
Volume:   333
Dimensions:   Width: 15.50cm , Height: 2.50cm , Length: 23.50cm
Weight:   0.864kg
ISBN:  

9781588295446

ISBN 10:   1588295443
Pages:   430
Publication Date:   01 March 2006
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Current Status of Renal Transplantation.- Current Status of Liver Transplantation.- Current Status of Clinical Islet Cell Transplantation.- Current Status of Lung Transplantation.- Chronic Rejection in the Heart.- Direct and Indirect Allorecognition.- HLA Typing and Its Influence on Organ Transplantation.- Strategies for Gene Transfer to Solid Organs.- Nonviral Vectors.- Detection and Clinical Relevance of Antibodies After Transplantation.- 11 Reprogramming the Immune System Using Antibodies.- In Vitro Assays for Immune Monitoring in Transplantation.- Proteomics and Laser Microdissection.- Real-Time Quantitative Polymerase Chain Reaction in Cardiac Transplant Research.- Organ Preservation.- Pharmacological Manipulation of the Rejection Response.- Experimental Models of Graft Arteriosclerosis.

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