Overview

This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.  

Full Product Details

Author:   Trevor W. Robbins ,  Barbara J. Sahakian
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2016
Volume:   28
Dimensions:   Width: 15.50cm , Height: 2.60cm , Length: 23.50cm
Weight:   7.664kg
ISBN:  

9783319816302

ISBN 10:   3319816306
Pages:   498
Publication Date:   30 May 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Translational mouse models of autism; Advancing towards pharmacological therapeutics.- Translatable and back-translatable measurement of impulsivity and compulsivity; convergent and divergent processes.- Translational models of gambling-related decision-making.- Translational research on nicotine dependence.- The need for treatment-responsive translatable biomarkers in alcoholism research.- On the road to translation for PTSD treatment: theoretical and practical considerations of the use of human models of conditioned fear for drug development.- Translational approaches targeting reconsolidation.- Translational assessment of reward and motivational deficits in psychiatric disorders.-                Affective biases in humans and animals. Robinson.- Locomotor profiling from the rodents to the clinic and back again.- Animal models of sensori-motor gating in schizophrenia: Are they still relevant?.- Attention and the cholinergic system: relevance to schizophrenia.- Attentional-set-shifting across species.- Relating Translational Neuroimaging and Amperometric Endpoints: Utility for Neuropsychiatric Drug Discovery.- Cognitive translation using the rodent touchscreen test approach.- The Paired Associates Learning (PAL) Test:  30 years of CANTAB Translational Neuroscience From Laboratory to Bedside in Dementia Research.- Translational approaches to experimental medicine.

Reviews

This book examines the 'translational gap' between animal models of neuropsychiatric disease and human studies. ... The intended audience is scientists working on problems related to neuropsychopharmacology. ... This is an important addition to the literature on translational neurosciences. It is an important contribution to understanding both the current state of this field and its possible future directions. (Eric Gausche, Doody's Book Reviews, November, 2016)

“This book examines the ‘translational gap’ between animal models of neuropsychiatric disease and human studies. … The intended audience is scientists working on problems related to neuropsychopharmacology. … This is an important addition to the literature on translational neurosciences. It is an important contribution to understanding both the current state of this field and its possible future directions.” (Eric Gausche, Doody's Book Reviews, November, 2016)

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