Signal Transduction and the Coordination of B Lymphocyte Development and Function II: Translation of BCR Signals to Specific Physiologic Outcomes
Author:   Louis B. Justement ,  Katherine A. Siminovitch
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Edition:   2000 ed.
Volume:   245/2
ISBN:  

9783540660033


Pages:   172
Publication Date:   19 August 1999
Format:   Hardback
Availability:   Out of stock   Availability explained
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Signal Transduction and the Coordination of B Lymphocyte Development and Function II: Translation of BCR Signals to Specific Physiologic Outcomes


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Overview

This volume provides a review of current research in the field of B cell development and differentiation with particular emphasis on signal transduction processes. The volume is divided into two parts that focus, respectively, on the basic biochemical pathways which regulate B cell biology and the role of signal transduction processes in regulating various aspects of B cell function, development and differentiation. In this second part the molecular processes involved in translating BCR engagement to specific biological outcomes are reviewed. Topics covered in this part include signal transduction via the pre-B cell antigen receptor complex, the control of immunoglobulin gene recombination and allelic exclusion, and molecular regulation of positive and negative selection. These latter chapters present information regarding processes which are critical for the B cell response to foreign antigen that leads to differentiation into antibody secreting plasma.

Full Product Details

Author:   Louis B. Justement ,  Katherine A. Siminovitch
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2000 ed.
Volume:   245/2
Dimensions:   Width: 15.50cm , Height: 1.20cm , Length: 23.50cm
Weight:   0.465kg
ISBN:  

9783540660033


ISBN 10:   3540660038
Pages:   172
Publication Date:   19 August 1999
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock   Availability explained
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

List of Contents.- B-Cell Antigen Receptor Signaling in Immature-Stage B Cells: Integrating Intrinsic and Extrinsic Signals.- Signaling Pathways that Control V(D)J Recombination.- B-Cell-Receptor-Dependent Positive and Negative Selection in Immature B Cells.- CD40-CD154 Interactions in B-Cell Signaling.- B-Lymphocyte Signaling Receptors and the Control of Class-II Antigen Processing.- Molecular Processes that Regulate Class Switching.

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