Overview

This book focuses on transgenerational toxicology using Caenorhabditis elegans as a model organism. C. elegans provides a powerful system for assessing toxic effects across generations because of its high sensitivity to environmental exposures and short life cycle. This book systematically presents current knowledge on the mechanisms underlying transgenerational toxicity, including toxicant translocation, biological barriers, intergenerational signaling, metabolic regulation, GPCR and nuclear hormone receptor pathways, and epigenetic control. It integrating protective responses and molecular regulatory networks, and offers readers a comprehensive framework for understanding and investigating transgenerational toxic effects in environmental and molecular toxicology research. This book serves as a valuable reference for researchers and graduate students in related areas of research.

Full Product Details

Author:   Dayong Wang
Publisher:   Springer Verlag, Singapore
Imprint:   Springer Nature
ISBN:  

9789819213887

ISBN 10:   9819213886
Pages:   272
Publication Date:   19 May 2026
Audience:   College/higher education ,  Postgraduate, Research & Scholarly ,  Undergraduate
Format:   Hardback
Publisher's Status:   Active
Availability:   Not yet available  
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Table of Contents

Chapter 1. Research Value of C. elegans for the Study of Transgenerational Toxicology.- Chapter 2. Transgenerational Toxicity at Various Aspects.- Chapter 3. Factor Affecting Transgenerational Toxicity.- Chapter 4. Roles of Transgenerational Translocation and Biological Barrier in Controlling Transgenerational Toxicity of Pollutants.- Chapter 5. Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline Insulin Signals.- Chapter 6. Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline Wnt Signals.- Chapter 7. Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline Hedgehog Signals.- Chapter 8. Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline FGF Signals.- Chapter 9. Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline Notch Signals.- Chapter 10. Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline Ephrin Signals.- Chapter 11. Regulation of Transgenerational Toxicity by Transgenerational Communication of Germline Neurotransmitter Signals.- Chapter 12. Regulation of Transgenerational Toxicity by Metabolic Signals.- Chapter 13. Regulation of Transgenerational Toxicity by Germline Small RNAs and RNAi-Associated Signaling.- Chapter 14. Regulation of Transgenerational Toxicity by Germline Methylation and Acetylation Related Signals.- Chapter 15. Regulation of Transgenerational Toxicity by Germline G Protein-Coupled Receptors and Nuclear Hormone Receptors.- Chapter 16. Protective Responses Against Transgenerational Toxicity.- Chapter 17. Basic Conclusions for Transgenerational Toxicology in Caenorhabditis elegans.

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Author Information

Dr. Dayong Wang is a professor at the Medical School, Southeast University, China. He obtained his Ph.D. from Peking University in 2001 and completed his post-doctoral training at the University of Toronto from 2002 to 2004. His research focuses on toxicology and pathology using Caenorhabditis elegans as a model animal, fields in which he has published more than 340 research articles. Dr. Wang has published five books with Springer, all of which are centered on the toxicology in Caenorhabditis elegans.

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