Overview

Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.

Full Product Details

Author:   Trygve O Tollefsbol (Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Edition:   2nd edition
Weight:   1.090kg
ISBN:  

9780128163634

ISBN 10:   0128163631
Pages:   518
Publication Date:   21 May 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Generational epigenetic inheritance SECTION I Definitions and history of generational epigenetic inheritance 2. Definition of epigenetic transgenerational inheritance and biological impacts 3. Historical perspective of transgenerational epigenetics SECTION II Germline epigenetics 4. Epigenetic changes in the mammalian paternal germ line SECTION III Parental epigenetic inheritance 5. Maternal epigenetic inheritance 6. Paternal epigenetic inheritance SECTION IV Basic mechanisms/processes of epigenetic inheritance 7. Towards the molecular mechanisms of transgenerational epigenetic inheritance: insights from transgenic mice 8. Histone-mediated transgenerational epigenetics 9. Heritable generational epigenetic effects through small noncoding RNA 10. Long noncoding RNA and epigenetic inheritance SECTION V Model organisms 11. Nonmammalian model organisms in epigenetic research:an overview 12. Plant models of transgenerational epigenetic inheritance 13. Epigenetics and heritable phenotypic variations in livestock 14. Transgenerational epigenetic inheritance in insects SECTION VI Evolution of transgenerational epigenetics 15. Evolutionary perspectives on transgenerational epigenetics 16. Inheritance of epigenome variants across generations during evolution SECTION VII Environmental epigenetic effects on the offspring 17. Transgenerational epigenetics of endocrine-disrupting chemicals in mammals 18. Transgenerational effects of imprinting 19. Epigenetic inheritance across multiple generations SECTION VIII Impact of transgenerational epigenetics on disease 20. Transgenerational epigenetics, paternal obesity, and insulin resistance 21. Epigenetic inheritance of type 2 diabetes SECTION IX Clinical significance of transgenerational epigenetics 22. Clinical aspects of transgenerational epigenetics

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Author Information

Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

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