Overview

""Toxoplasma gondii"" is an important parasite causing economic losses in agriculture, congenital abnormalities in man and fatal disease in immunosuppressed individuals. Recently there has been a resurgence of interest in the parasite. This is partially due to the increased clinical importance of toxoplasmosis: the disease kills 25 % of AIDS patients. However, hit is also because the parasite provides a tractable model system for molecular, cellular and immunological investigation of intracellular parasites. The book is divided into four sections: three basic science sections on molecular biology, cell biology, and immunology of toxoplasmosis, with a final section reviewing applied issues such as vaccination, chemotherapy, and diagnosis.

Full Product Details

Author:   Judith E. Smith
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   v. 78
Weight:   0.530kg
ISBN:  

9783540573050

ISBN 10:   3540573054
Pages:   273
Publication Date:   20 December 1993
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Molecular Biology.- Allelic polymorphyism in Toxoplasma gondii: implications for interstrain mating.- Study of genetic polymorphism of Toxoplasma gondii through isoenzyme analysis.- Expression of apical organelle antigens by a Toxoplasma gondii genomic library.- Dense granule antigens of Toxoplasma gondii.- A strategy for cloning a DNA polymerase gene of Toxoplasma gondii.- Extrachromosomal DNA in the Apicomplexa.- Cell Biology.- Formation and modification of the parasitophorous vacuole occupied by Toxoplasma gondii.- The parasitophorous vacuole membrane surrounding T. gondii: a specialized interface between parasite and cell.- Toxoplasma gondii: Motility and Invasion.- Toxoplasma gondii: Patterns of bradyzoite-tachyzoite interconversion in vitro.- The growth and development of Toxoplasma gondii tissue cysts in vitro.- Recent advances in the glycobiology of Toxoplasma gondii.- Immunology.- Role of P30 in attachment and immunity to T gondii.- Secretory IgA, antibody to SAG1, H-2 class I-restricted CD8+ T-lymphocytes and the INT1 locus in protection against Toxoplasma gondii.- Factors responsible for development of toxoplasmic enchephalitis in immunocompromised hosts.- Synergistic and compensatory roles of CD4+, CD8 + T-lymphocytes and natural killer cells in resistance to Toxoplasma gondii.- Human T-cell clones as tools to identify protective antigens of Toxoplasma gondii.- Protection of mice and nude rats against Toxoplasmosis by an octomaeric construct of the P30 48-67 peptide.- Toxoplasmosis Vaccines Diagnosis & Chemotherapy.- Synergistic drug combinations in the treatment of toxoplasmosis.- Toxoplasma gondii: Chemotherapy.- Diagnosis of Toxoplasma gondii infections by molecular detection.- Use of Toxoplasma gondii recombinant antigens for diagnosis and seroepidemiology.- Progress towards the development of a vaccine against congenital toxoplasmosis: Identification of protective antigens and the selection of appropriate adjuvants.- Development of a live vaccine against ovine toxoplasmosis.- Abstracts.- Genetic regulation of Toxoplasma gondii infection: influence of LSH/ITY/BCG gene.- Establishing a laboratory for parasitic genome analysis: focus on the parasitic protozoa Toxoplasma, Trypanosoma and Leishmania.- Mucosal immune response in Tpxoplasmosis.- Antenatal screening for Toxoplasmosis in Turkiye.- Toxoplasmosis in Greece: Serological studies.- Critical evaluation of IgA antibodies as an indication of early Toxoplasma-infection.- Expression of Toxoplasma gondii genes in rBCG.

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