Toxicological Risk Assessment: Biological and Statistical Criteria

Author:   David B. Clayson (Consultant, Carp, Ontario, Canada) ,  Daniel R. Krewski ,  Ian C. Munro (University of Guelph)
Publisher:   Taylor & Francis Ltd
Volume:   1
ISBN:  

9780367258009


Pages:   244
Publication Date:   27 August 2019
Format:   Hardback
Availability:   In Print   Availability explained
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Toxicological Risk Assessment: Biological and Statistical Criteria


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Author:   David B. Clayson (Consultant, Carp, Ontario, Canada) ,  Daniel R. Krewski ,  Ian C. Munro (University of Guelph)
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Volume:   1
Weight:   0.610kg
ISBN:  

9780367258009


ISBN 10:   0367258005
Pages:   244
Publication Date:   27 August 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Volume I. SECTION A - BIOLOGICAL CRITERIA. 1. Interspecies Exploration of Drug and Genetic Toxicity Data. 2. Pharmacokinetic Differences Between Species. 3. Differences in Metabolism at Different Dose Levels. 4. Toxicological Effects on Carcinogenesis. 5. Problems in Interspecies Exploration. SECTION B - STATISTICAL CRITERIA. 6. Statistical Design and Analysis of the Long-Term Carcinogenicity Bioassay. 7. Statistical Analysis of Rodent Tumorigenicity Experiments. 8. Use of the Hartley-Sielken Model in Low-Dose Extrapolation. 9. A Review of Methods for Calculating Statistical Confidence Limits in Low-Dose Extrapolation. 10. Incorporation of Pharmacokinetics in Low-Dose Risk Estimation. Index. Volume II. SECTION A - GENERAL CRITERIA. 1. Epidemiological Methods for the Assessment of Human Cancer at Risk. 2. Assessment of Human Exposure to Environmental Contaminants with Special Reference. 3. The Influence of Nutrition, Immunologic Status, and Other Factors on the Development of Cancer. 4. The Significance of Benefits in Regulatory Decision Making. 5. Measuring Health Benefits. 6. Food Safety Regulations. SECTION B - CASE STUDIES 7. Case Study - Asbestos. 8. Vinyl Chloride - A Cancer Case Study. 9. An Integrated Approach to the Study of Formaldehyde Carcinogenicity in Rats and Mice. 10. Determination of Human Risk in Regulating Polychlorinated Biphenyls (PCBs) - A Case Study. 11. Saccharin - A Bitter Sweet Case. Index.

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D. B. Clayson, D. Krewski, I. Munro

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