Overview

This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues. It explores the tissue-antigen and antibody-specific problems that may be encountered during the staining procedures and provide potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents, monkeys and aquatic animal tissues.

Full Product Details

Author:   Syed A. Aziz ,  Rekha Mehta
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   1st ed. 2016
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   4.912kg
ISBN:  

9781493915156

ISBN 10:   1493915150
Pages:   231
Publication Date:   24 December 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1.Immunohistochemistry – Overview, Its Potential and Challenges.- 2.Tissue Micro Array (TMA) Technology and its Potential Applications in Toxicology and Toxicological Immunohistochemistry.- 3.Importance of Fluorescent In Situ Hybridization (FISH) in Rodent Tumors.- 4.Quantitation of Immunohistochemistry by Image Analysis Technique.- 5.Immunohistochemistry in the Study of Cancer Biomarkers for Oncology Drug Development.- 6.Male Reproductive Toxicology and the Role of Immunohistochemistry.- 7. Immunohistochemistry and Female Reproductive Toxicology: The Ovary and Mammary Gland.- 8.Immunohistochemistry on Rodent Circulatory System: Its Possible Use in Investigating Hypertension.- 9.Role of Lymphoid/Mucosa-Associated Lymphoid Tissue Markers in Toxicological Immunohistochemistry. 10.Bone Markers and Immunohistochemistry Changes in Toxic Environments.- 11. Biomarkers of Skeletal Muscle Injury in the Rat.

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Author Information

Syed A Aziz, Ph.D. Regulatory Toxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch Health Canada Adjunct professor, Faculty of Medicine Dept. of Pathology University of Ottawa Rekha Mehta, Ph.D. Regulatory Toxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch Health Canada.

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