Overview

This text evaluates the design and findings of studies relevant to the safety assessment of selected veterinary drug residues in food. It aims to give toxicologists, the food industry, and regulatory agencies a record of the scientific evidence considered when the Committee allocates or revises acceptable daily intakes and other endpoints. Emphasis is placed on studies that relate specific exposure levels to specific toxic effects or guide the meaningful expolation of animal data to the human condition. Through its attention to questions of study design, methodology, and the validity of reported data, the book also seeks to demonstrate the strict safety standards used by JECFA in its efforts to protect consumers from any possible toxicological or pharmacological hazard linked to the consumption of veterinary drug residues. Separe toxicological monographs are presented for four anthelminthic agents (eprinomectin, febantel, fenbendazole, and oxfendazole), three antimicrobial agents (gentamicin, sarafloxacin, and tetracyclines), three antiprotozoal agents (diclazuril, imidocarb, and nicarbazin), one production aid (recombinant bovine somatotropins), and one tranquilizing agent (azaperone).

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