Overview

This text details in vivo and in vitro techniques for measuring the absorption of pharmaceutical and cosmetic compounds by the skin. It discusses factors that affect skin penetration, including age, delivery vehicle, metabolism, hydration and chemical structure. Specific examples of the absorption of various topical products such as alpha hydroxy acids, sunscreens, fragrances and hair dyes are given.

Full Product Details

Author:   Robert L. Bronaugh (Food & Drug Administration, College Park, Maryland, USA) ,  Howard I. Maibach (University of California School of Medicine, Department of Dermatology, San Francisco, USA)
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Volume:   v. 21
Dimensions:   Width: 21.60cm , Height: 3.00cm , Length: 27.90cm
Weight:   0.862kg
ISBN:  

9780824706265

ISBN 10:   0824706269
Pages:   544
Publication Date:   02 January 2002
Audience:   College/higher education ,  Professional and scholarly ,  General/trade ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Stock Indefinitely
Availability:   Out of stock  

Table of Contents

Mechanisms of Absorption Cutaneous Metabolism During In Vitro Percutaneous Absorption Robert L. Bronaugh, Margaret E. K. Kraeling, Jeffrey J. Yourick, and Harolyn L. Hood Occlusion Does Not Uniformly Enhance Penetration In Vivo Daniel A. W. Bucks and Howard I. Maibach Regional Variation in Percutaneous Absorption Ronald C. Wester and Howard I. Maibach The Development of Skin Barrier Function in the Neonate Lourdes B. Nonato, Yogeshvar N. Kalia, Aarti Naik, Carolyn H. Lund, and Richard H. Guy Cutaneous Metabolism of Xenobiotics Saqib J. Bashir and Howard I. Maibach Percutaneous Drug Delivery to the Hair Follicle Andrea C. Lauer In Vivo Relationship Between Percutaneous Absorption and Transepidermal Water Loss Andre Rougier, Claire Lotte, and Howard I. Maibach Dermal Decontamination and Percutaneous Absorption Ronald C. Wester and Howard I. Maibach Methodology In Vivo Methods for Percutaneous Absorption Measurement Ronald C. Wester and Howard I. Maibach Determination of Percutaneous Absorption by In Vitro Techniques Robert L. Bronaugh, Harolyn L. Hood, Margaret E. K. Kraeling, and Jeffrey J. Yourick Systemic Absorption of Cutaneous Material Robert L. Bronaugh and Harolyn L. Hood Interrelationships in the Dose-Response of Percutaneous Absorption Ronald C. Wester and Howard I. Maibach Effect of Single Versus Multiple Dosing in Percutaneous Absorption Ronald C. Wester and Howard I. Maibach Blood Flow as a Technology in Percutaneous Absorption: The Assessment of the Cutaneous Microcirculation by Laser Doppler and Photoplethysmographic Techniques Ethel Tur Drug Concentration in the Skin Christian Surber, Eric W. Smith, Fabian P. Schwarb, Tatiana Tassopoulos, and Howard I. Maibach Stripping Method for Measuring Percutaneous Absorption In Vivo Andre Rougier, Didier Dupuis, Claire Lotte, and Howard I. Maibach Interference with Stratum Corneum Lipid Biogenesis: An Approach to Enhance Transdermal Drug Delivery Peter M. Elias, Vivien Mak, Carl Thornfeldt, and Kenneth R. Feingold Methods for the Assessment of Topical Corticosteroid-Induced Skin Blanching John M. Haigh, Eric W. Smith, Carryn H. Purdon, and Howard I. Maibach Importance of In Vitro Release Measurement in Topical Dermatological Dosage Forms Vinod P. Shah, Jerome S. Elkins, and Roger L. Williams Innovative Methods to Determine Percutaneous Absorption in Humans: Real-Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling Karla D. Thrall, Torka S. Poet, Richard A. Corley, Howard I. Maibach, and Ronald C. Wester Calculations of Body Exposure from Percutaneous Absorption Data Richard H. Guy and Howard I. Maibach Drug and Cosmetic Absorption Percutaneous Penetration as a Method of Delivery to Skin and Underlying Tissues Parminder Singh Phonophoresis Joseph Kost, Samir Mitragotri, and Robert Langer Facilitated Transdermal Delivery by Iontophoresis Parminder Singh, Puchun Liu, and Steven M. Dinh Percutaneous Penetration as It Relates to the Safety Evaluation of Cosmetic Ingredients Jeffrey J. Yourick and Robert L. Bronaugh Percutaneous Absorption of Fragrances Jeffrey J. Yourick, Harolyn L. Hood, and Robert L. Bronaugh Hair Dye Absorption Leszek J. Wolfram Percutaneous Absorption of Alpha-Hydroxy Acids Margaret E. K. Kraeling and Robert L. Bronaugh Optimizing Patch Test Delivery: A Model Ronald C. Wester and Howard I. Maibach Nail Penetration: Focus on Topical Delivery of Antifungal Drugs for Onychomycosis Treatment Ying Sun, Jue-Chen Liu, Jonas C. T. Wang, and Piet De Doncker Topical Dermatological Vehicles: A Holistic Approach Eric W. Smith, Christian Surber, Tatiana Tassopoulos, and Howard I. Maibach Percutaneous Absorption of Sunscreens Kenneth A. Walters and Michael S. Roberts Colloidal Drug Carrier Systems Konstanze Jahn, Annett Krause, Martin Janich, and Reinhard H. H. Neubert Alternative Therapies-Calling Up the Reserves: A Topical Nonsteroidal Formulary for the Management of Acute, Subacute, and Chronic Steroid-Responsive Dermatoses and Other Skin Afflictions Jerome Z. Litt Ointments, Creams, and Lotions Used as Topical Drug Delivery Vehicles Christian Surber, Tatiana Tassopoulos, and Eric W. Smith Index

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a worthy and comprehensive reference book. contains a wealth of information. -ISSX Newsletter

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