Toll-Like Receptor Family Members and Their Ligands
Author:   Bruce Beutler ,  Hermann Wagner (Technische Universitat Munich, Germany)
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Volume:   v. 270
ISBN:  

9783540435600


Pages:   202
Publication Date:   19 September 2002
Format:   Hardback
Availability:   Out of stock   Availability explained
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Toll-Like Receptor Family Members and Their Ligands


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Overview

The innate immune system is sometimes referred to as the ""primitive"" immune system. Perhaps this has dissuaded immunologists from analyzing it so energetically as they have analyzed the adaptive immune system during the past two decades. But while its phylogenetic origins are indeed ancient, and though it is ""of the first type"", there is nothing crude, nothing unsophisticated, and nothing ""inferior"" about innate immunity. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last due.

Full Product Details

Author:   Bruce Beutler ,  Hermann Wagner (Technische Universitat Munich, Germany)
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   v. 270
Weight:   0.418kg
ISBN:  

9783540435600


ISBN 10:   3540435603
Pages:   202
Publication Date:   19 September 2002
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock   Availability explained
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Evolution of the TIR, Tolls and TLRs: Functional Inferences from Computational Biology.-Plant Disease Resistance: Commonality and Novelty in Multicellular Innate Immunity.-Superfamily Signal Transduction Pathways Activated by the IL-1 Receptor/Toll-Like Receptor.-Toll Receptors in Drosophila: A Family of Molecules Regulating Development and Immunity.-Toll-Like Receptors and Their Ligands.-Toll-Like Receptor-5 and the Innate Immune Response to Bacterial Flagellin.-TLR4 as the Mammalian Endotoxin Sensor.-TLR2: Cellular Sensor for Microbial and Endogenous Molecular Patterns.-Bacterial CpG-DNA Licenses TLR9.-MyD88 as a Bottle Neck in Toll/IL-1 Signaling.-Heat Shock Proteins as Ligands of Toll-Like Receptors.-Subject Index.

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