Overview

It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer. TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.

Full Product Details

Author:   Hao Wu
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of hardcover 1st ed. 2007
Volume:   597
Dimensions:   Width: 15.50cm , Height: 1.20cm , Length: 23.50cm
Weight:   0.441kg
ISBN:  

9781441924209

ISBN 10:   1441924205
Pages:   206
Publication Date:   19 November 2010
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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