Overview

This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.

Full Product Details

Author:   Lorenza González-Mariscal
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2022
Weight:   0.688kg
ISBN:  

9783030972035

ISBN 10:   3030972038
Pages:   334
Publication Date:   01 June 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Tight Junction book  Table of Contents Chapter 1: A historical and evolutionary view of tight junctions. Marcelino Cereijido Chapter 2: Tricellular tight junctions. Mikio Furuse and Tomohito Higashi Chapter 3: Mechanosensitivity of tight junctions. Alpha S. Yap Chapter 4: Intracellular traffic and non-canonical roles of ZO-2 protein. Lorenza González-Mariscal Chapter 5: Impact of claudin-2 and occludin expression in inflammation disorders. Jerrold R. Turner Chapter 6: Tight junctions in the inflamed gut. Porfirio Nava Chapter 7: Intestinal barrier disruption by enteropathogenic Escherichia coli. Gail Hecht and Rocio Tapia Chapter 8: Tight junction barrier function regulation by microbiota. Sean Colgan Chapter 9: Claudin-7 participation in cell-substrate adhesion, cell migration, salt balance in the renal collecting duct and gut cell renewal and differentiation. Yan-Hua Chen Chapter 10: Regulation of the alveolar epithelial barrier by claudin-5. Michael Koval Chapter 11: Regulation of the blood-retinal barrier by occludin phosphorylation, norrin and sonic hedgehog signaling. David Antonetti and Monica Diaz-Coranguez Chapter 12: Transmigration of metastatic cells through the blood-brain barrier. István Krizbai and Imola Wilhelm Chapter 13: Endocytosis of tight junction proteins. Anuska Andjelkovic  Chapter 14: Regulated degradation of claudins. Gerardo Contreras.

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Author Information

Dr. Lorenza González-Mariscal is a Profesor Titular in the Departamento de Fisiología Biofísica y Neurociencias, at the Centro de Investigación y Estudios Avanzados in Mexico City, Mexio. 

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