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OverviewThis massive revision of the highly acclaimed first edition presents a wealth of new information and insights on every aspect of the etiology, pathogenesis, diagnosis, initial treatment, and long-term management of all varieties of thyroid cancer. Paramount is a thorough treatment of the nuclear medical aspects of diagnosing and managing the thyroid cancer patient. This includes extensive discussion of isotopes, isotope uptake and scanning procedures, radioisodine ablation and dosimetry (with or without recombinant human TSH), stunning, octreotide and FDG-PET scanning, and various alternative imaging modalities. Additional highlights include management of the scan negative and thyroglobulin-positive patient, ultrasound of the lymph nodes, local adjuncts to therapy of metastases, low iodine diets and cookbooks, future directions in therapy, and alternative therapies when traditional surgery and radioactive iodine fail. Full Product DetailsAuthor: Leonard Wartofsky , Douglas Van NostrandPublisher: Humana Press Inc. Imprint: Humana Press Inc. Edition: 2nd ed. 2006 Dimensions: Width: 17.80cm , Height: 3.80cm , Length: 25.40cm Weight: 1.813kg ISBN: 9781617375835ISBN 10: 1617375837 Pages: 708 Publication Date: 17 September 2011 Audience: Professional and scholarly , Professional & Vocational Replaced By: 9781493933129 Format: Paperback Publisher's Status: Active Availability: Awaiting stock ![]() The supplier is currently out of stock of this item. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out for you. Table of ContentsGeneral Considerations I.- Anatomy and Physiology of the Thyroid Gland.- Epidemiology of Thyroid Cancer.- Molecular Pathogenesis of Thyroid Cancer.- Molecular Aspects of Thyroid Cancer in Children.- Oncogenes in Thyroid Cancer.- Apoptosis in Thyroid Cancer.- Radiation-Induced Thyroid Cancer.- Classification of Thyroid Malignancies.- Staging of Thyroid Cancer.- Thyroid Cancer in Children and Adolescents.- Recombinant Human Thyrotropin.- General Considerations II.- History of the Role of Nuclear Medicine in the Thyroid Gland and its Diseases.- Prophylaxis Against Radiation Exposure from Radioiodine.- Radioiodine Whole Body Imaging.- Primer and Atlas for the Interpretation of Radioiodine Whole-Body Scintigraphy.- False-Positive Radioiodine Scans in Thyroid Cancer.- The Thyroid Nodule.- The Thyroid Nodule.- Fine-Needle Aspiration.- Thyroid Nodules.- Radionuclide Imaging of Thyroid Nodules.- Ultrasonic Imaging of the Neck in Patients with Thyroid Cancer.- Thyroid Nodules and Cancer Risk.- Well-Differentiated Thyroid Cancer: Papillary Carcinoma.- Papillary Carcinoma.- Surgical Approach to Papillary Carcinoma.- Papillary Carcinoma.- Well-Differentiated Thyroid Cancer.- Prescribed Activity for Radioiodine Ablation.- Thyroid Remnant Radioiodine Ablation with Recombinant Human Thyrotropin.- Well-Differentiated Thyroid Cancer.- Follow-Up Strategy in Papillary Thyroid Cancer.- Levothyroxine Therapy and Thyrotropin Suppression.- Thyroglobulin and Thyroglobulin Antibodies.- Diagnosis of Recurrent Thyroid Cancer in Patients with Antithyroglobulin Antibodies.- Surveillance Radioiodine Whole-Body Scans.- Radionuclide Imaging and Treatment of Thyroid Cancer in Children.- Positron Emission Tomography in Well-Differentiated Thyroid Cancer.- Alternative Thyroid Imaging.- Stunning: UntowardEffect of 131I Thyroid Imaging Prior to Radioablation Therapy.- Stunning Is Not a Problem.- Stunning: Does it Exist? A Commentary.- Ultrasonic Imaging and Identification of Metastases in Cervical Lymph Nodes.- Magnetic Resonance Imaging and Computed Tomography of Thyroid Cancer.- Management of the Patients with Negative Radioiodine Scan and Elevated Serum Thyroglobulin.- Determinants of Prognosis in Papillary Thyroid Cancer.- Papillary Cancer.- Special Presentations of Thyroid Cancer in Pregnancy, Renal Failure, Thyrotoxicosis, and Struma Ovarii.- Thyroglossal Duct Carcinoma.- Well-Differentiated Thyroid Cancer.- Radiation and Radioactivity.- Radioiodine Treatment of Distant Metastases.- 131I Treatment of Metastatic Thyroid Carcinoma Following Preparation by Recombinant Human Thyrotropin.- Dosimetry.- Radioiodine Dosimetry with Recombinant Human Thyrotropin.- Use of Lithium as an Adjuvant to Radioiodine in the Treatment of Thyroid Cancer.- Side Effects of 131I for Ablation and Treatment of Well-Differentiated Thyroid Carcinoma.- External Radiation Therapy of Papillary Cancer.- Chemotherapy for Thyroid Cancer.- Chemotherapy of Differentiated Papillary or Follicular Thyroid Carcinoma.- Thyroid Carcinoma.- Adjunctive Local Approaches to Metastatic Thyroid Cancer.- Well-Differentiated Thyroid Cancer.- Follicular Thyroid Carcinoma.- Surgical Management of Follicular Cancer.- Pathology of Follicular Cancer.- Hürthle Cell Carcinoma.- Radionuclide Imaging, Ablation, and Treatment in Follicular Thyroid Carcinoma.- Follow-up Strategy in Follicular Thyroid Cancer.- PET in Follicular Cancer, Including Hürthle Cell Cancer.- Follicular Thyroid Cancer.- External Radiation Therapy of Follicular Carcinoma.- Determinants of Prognosis in Patients With Follicular Thyroid Cancer.-Variants of Thyroid Cancer.- Miscellaneous and Unusual Types of Thyroid Tumors.- Pathology of Miscellaneous and Unusual Cancers of the Thyroid.- Undifferentiated Tumors.- Clinical Aspects of Medullary Thyroid Carcinoma.- Pathology of Medullary Thyroid Cancer.- Medullary Carcinoma of the Thyroid.- Radionuclide Imaging of Medullary Carcinoma.- PET in Medullary Thyroid Cancer.- External Radiation Therapy of Medullary Cancer.- Medullary Carcinoma of the Thyroid.- Undifferentiated Tumors.- Thyroid Lymphoma.- Pathology of Lymphoma of the Thyroid.- FDG-PET Scanning in Lymphoma and Lymphoma of the Thyroid.- Undifferentiated Tumors.- Anaplastic Carcinoma.- Surgical Management of Anaplastic Thyroid Carcinoma.- Pathology of Anaplastic Carcinoma.- PET Scanning in Anaplastic Cancer of the Thyroid.- External Radiation Therapy of Anaplastic Thyroid Cancer.- Chemotherapy for Anaplastic Thyroid Cancer.- Anaplastic Carcinoma.- New Frontiers and Future Directions.- Advances in Radiation Therapy.- New Approaches in Nuclear Medicine for Thyroid Cancer.- Alternative Options and Future Directions for Thyroid Cancer Therapy.- Potential Approaches to Chemotherapy of Thyroid Cancer in the Future.- Resources for Patients with Thyroid Cancer.- Low Iodine Diets.ReviewsFrom the reviews ...our present state of knowledge provides clinicians a wide variety of diagnostic and therapeutic modalities to effectively manage this group of cancers. I believe the knowledge contained in this text will give the practicing clinician the necessary information to provide patients the latest and best therapeutic techniques. -Foreword by Ernest L. Mazzaferri, MD This is an excellent comprehensive up-to-date text that is scholarly and complete, yet thoroughly readable. It provides guidance to clinicians and others interested in thyroid cancer based on a combination of a distillate of the published literature [which is fully documented] and the personal experience of the expert author of each chapter. . .the text reads quickly. . . I recommend this text to anyone interested in an up-to-date, detailed, clinical guideline to the management of patients with thyroid cancer and the clinical science behind the recommendation. -Journal of Nuclear Medicine This book illustrates the importance of the multidisciplinary approach available in major medical centers for the care of patients with thyroid cancer. The wide-ranging topical nature of this book will interest those working in many fields of medicine. It should be essential reading for trainees in endocrinology, pathology, imaging, nuclear medicine, surgery, and oncology, as well as for specialists in those fields. -The New England Journal of Medicine The book is truly unique and is a critical addition to the contemporary endocrine texts held by general physicians, surgeons, and endocrinologists alike. The book is designed to be a comprehensive guide for clinical management of thyroid cancer and in this regard, is an overwhelming success...One of the most important aspects of this text is the multidisciplinary emphasis provided to all the sub specialists who attend patients with thyroid neoplasms... The book is uniquely organized with several chapters exclusively devoted to the surgical and medical management of individual types of thyroid cancer. This organization is important, because it helps emphasize that each thyroid cancer is unique and not necessarily amenable to one standardized form of treatment...A parallel emphasis of the book is the reliance on evidence-based practice...each chapter is thoroughly referenced, making it easy for the reader to ascertain the original studies on which these conclusions and controversy are based....One of the strengths of this book is the devotion of separate chapters to the management of unique thyroid cancers and unique patients...The text is right up -to- date with regards to the molecular biology of thyroid cancers, the management of medullary thyroid carcinoma, the use of alternative imaging techniques and the use of rhTSH for scanning patients with a history of thyroid cancer...To conclude, this is a unique and important text for all practitioners caring for patients with thyroid cancer. I congratulate the Editor and Authors for their success in detailing this complex and rapidly changing field. ------Trends in Endocrinology and Metabolism ...recommended for anyone who would like a comprehensive reference on the practical aspects of thyroid cancer management. - Head & Neck This comprehensive book brings an instructive review of present knowledge on the pathology, etiology, epidemiology, diagnostic methods and the methods of surgical, radioiodine and chemotherapeutic treatment of various forms of thyroid cancer. Written by outstanding experts and professionally edited by Leonard Wartofsky, it may be considered of substantial utility to all physicians dealing with thyroid diseases. - Endocrine Regulations From the reviews of the second edition: An excellent, truly comprehensive book that covers the etiology, pathogenesis, and clinical management of all forms of thyroid cancer. ... While the book is written clearly enough to be accessible to physicians in training, it will probably be most useful for practicing physicians. The targeted readers include endocrinologists, endocrine surgeons, nuclear medicine specialists, pathologists, and oncologists. ... This is an outstanding textbook ... . surely a work to be added to the library of every clinician taking care of patients with thyroid cancer. (Brian W. Kim, Doody's Review Service, May, 2006) This book includes almost twice as many chapters and contributors as the first edition. I especially enjoyed the addition of patient-focused content, including lists of useful books and Web sites and practical advice regarding radioiodine treatment ... . an excellent, up-to-date book that is of practical value across all specialties involved in the management of thyroid cancer. It also provides a scholarly overview of the evidence base. (Jayne Franklyn, The New England Journal of Medicine, July, 2006) This is the second edition of an outstanding textbook edited by Leonard Wartofsky and Douglas Van Nostrand. The editors are to be congratulated on bringing together a remarkable array of multidisciplinary authors, who cover every topic pertaining to the clinical management of thyroid cancer. ... Overall, I would highly recommend this book to all practitioners and associated specialties involved in the management of thyroid cancer. The book is clearly and concisely written, well illustrated ... . an excellent textbook. (John Watkinson, Annals of the Royal College of Surgeons of England, Vol. 90, June, 2008) From the reviews ...our present state of knowledge provides clinicians a wide variety of diagnostic and therapeutic modalities to effectively manage this group of cancers. I believe the knowledge contained in this text will give the practicing clinician the necessary information to provide patients the latest and best therapeutic techniques. -Foreword by Ernest L. Mazzaferri, MD This is an excellent comprehensive up-to-date text that is scholarly and complete, yet thoroughly readable. It provides guidance to clinicians and others interested in thyroid cancer based on a combination of a distillate of the published literature [which is fully documented] and the personal experience of the expert author of each chapter...the text reads quickly... I recommend this text to anyone interested in an up-to-date, detailed, clinical guideline to the management of patients with thyroid cancer and the clinical science behind the recommendation. -Journal of Nuclear Medicine This book illustrates the importance of the multidisciplinary approach available in major medical centers for the care of patients with thyroid cancer. The wide-ranging topical nature of this book will interest those working in many fields of medicine. It should be essential reading for trainees in endocrinology, pathology, imaging, nuclear medicine, surgery, and oncology, as well as for specialists in those fields. -The New England Journal of Medicine The book is truly unique and is a critical addition to the contemporary endocrine texts held by general physicians, surgeons, and endocrinologists alike. The book is designed to be a comprehensive guide for clinical management of thyroid cancer and in this regard, is an overwhelming success...One of the most important aspects of this text is the multidisciplinary emphasis provided to all the sub specialists who attend patients with thyroid neoplasms... The book is uniquely organized with several chapters exclusively devoted to the surgical and medical management of individual types of thyroid cancer. This organization is important, because it helps emphasize that each thyroid cancer is unique and not necessarily amenable to one standardized form of treatment...A parallel emphasis of the book is the reliance on evidence-based practice...each chapter is thoroughly referenced, making it easy for the reader to ascertain the original studies on which these conclusions and controversy are based...One of the strengths of this book is the devotion of separate chapters to the management of unique thyroid cancers and unique patients...The text is right up -to- date with regards to the molecular biology of thyroid cancers, the management of medullary thyroid carcinoma, the use of alternative imaging techniques and the use of rhTSH for scanning patients with a history of thyroid cancer...To conclude, this is a unique and important text for all practitioners caring for patients with thyroid cancer. I congratulate the Editor and Authors for their success in detailing this complex and rapidly changing field. ------Trends in Endocrinology and Metabolism ...recommended for anyone who would like a comprehensive reference on the practical aspects of thyroid cancer management. - Head & Neck This comprehensive book brings an instructive review of present knowledge on the pathology, etiology, epidemiology, diagnostic methods and the methods of surgical, radioiodine and chemotherapeutic treatment of various forms of thyroid cancer. Written by outstanding experts and professionally edited by Leonard Wartofsky, it may be considered of substantial utility to all physicians dealing with thyroid diseases. - Endocrine Regulations From the reviews of the second edition: An excellent, truly comprehensive book that covers the etiology, pathogenesis, and clinical management of all forms of thyroid cancer. ! While the book is written clearly enough to be accessible to physicians in training, it will probably be most useful for practicing physicians. The targeted readers include endocrinologists, endocrine surgeons, nuclear medicine specialists, pathologists, and oncologists. ! This is an outstanding textbook ! . surely a work to be added to the library of every clinician taking care of patients with thyroid cancer. (Brian W. Kim, Doody's Review Service, May, 2006) This book includes almost twice as many chapters and contributors as the first edition. I especially enjoyed the addition of patient-focused content, including lists of useful books and Web sites and practical advice regarding radioiodine treatment ! . an excellent, up-to-date book that is of practical value across all specialties involved in the management of thyroid cancer. It also provides a scholarly overview of the evidence base. (Jayne Franklyn, The New England Journal of Medicine, July, 2006) This is the second edition of an outstanding textbook edited by Leonard Wartofsky and Douglas Van Nostrand. The editors are to be congratulated on bringing together a remarkable array of multidisciplinary authors, who cover every topic pertaining to the clinical management of thyroid cancer. ! Overall, I would highly recommend this book to all practitioners and associated specialties involved in the management of thyroid cancer. The book is clearly and concisely written, well illustrated ! . an excellent textbook. (John Watkinson, Annals of the Royal College of Surgeons of England, Vol. 90, June, 2008) From the reviews ...our present state of knowledge provides clinicians a wide variety of diagnostic and therapeutic modalities to effectively manage this group of cancers. I believe the knowledge contained in this text will give the practicing clinician the necessary information to provide patients the latest and best therapeutic techniques. -Foreword by Ernest L. Mazzaferri, MD This is an excellent comprehensive up-to-date text that is scholarly and complete, yet thoroughly readable. It provides guidance to clinicians and others interested in thyroid cancer based on a combination of a distillate of the published literature [which is fully documented] and the personal experience of the expert author of each chapter...the text reads quickly... I recommend this text to anyone interested in an up-to-date, detailed, clinical guideline to the management of patients with thyroid cancer and the clinical science behind the recommendation. -Journal of Nuclear Medicine This book illustrates the importance of the multidisciplinary approach available in major medical centers for the care of patients with thyroid cancer. The wide-ranging topical nature of this book will interest those working in many fields of medicine. It should be essential reading for trainees in endocrinology, pathology, imaging, nuclear medicine, surgery, and oncology, as well as for specialists in those fields. -The New England Journal of Medicine The book is truly unique and is a critical addition to the contemporary endocrine texts held by general physicians, surgeons, and endocrinologists alike. The book is designed to be a comprehensive guide for clinical management of thyroid cancer and in this regard, is an overwhelming success...One of the most important aspects of this text is the multidisciplinary emphasis provided to all the sub specialists who attend patients with thyroid neoplasms... The book is uniquely organized with several chapters exclusively devoted to the surgical and medical management of individual types of thyroid cancer. This organization is important, because it helps emphasize that each thyroid cancer is unique and not necessarily amenable to one standardized form of treatment...A parallel emphasis of the book is the reliance on evidence-based practice...each chapter is thoroughly referenced, making it easy for the reader to ascertain the original studies on which these conclusions and controversy are based...One of the strengths of this book is the devotion of separate chapters to the management of unique thyroid cancers and unique patients...The text is right up -to- date with regards to the molecular biology of thyroid cancers, the management of medullary thyroid carcinoma, the use of alternative imaging techniques and the use of rhTSH for scanning patients with a history of thyroid cancer...To conclude, this is a unique and important text for all practitioners caring for patients with thyroid cancer. I congratulate the Editor and Authors for their success in detailing this complex and rapidly changing field. ------Trends in Endocrinology and Metabolism ...recommended for anyone who would like a comprehensive reference on the practical aspects of thyroid cancer management. - Head & Neck This comprehensive book brings an instructive review of present knowledge on the pathology, etiology, epidemiology, diagnostic methods and the methods of surgical, radioiodine and chemotherapeutic treatment of various forms of thyroid cancer. Written by outstanding experts and professionally edited by Leonard Wartofsky, it may be considered of substantial utility to all physicians dealing with thyroid diseases. - Endocrine Regulations From the reviews of the second edition: An excellent, truly comprehensive book that covers the etiology, pathogenesis, and clinical management of all forms of thyroid cancer. ! While the book is written clearly enough to be accessible to physicians in training, it will probably be most useful for practicing physicians. The targeted readers include endocrinologists, endocrine surgeons, nuclear medicine specialists, pathologists, and oncologists. ! This is an outstanding textbook ! . surely a work to be added to the library of every clinician taking care of patients with thyroid cancer. (Brian W. Kim, Doody's Review Service, May, 2006) This book includes almost twice as many chapters and contributors as the first edition. I especially enjoyed the addition of patient-focused content, including lists of useful books and Web sites and practical advice regarding radioiodine treatment ! . an excellent, up-to-date book that is of practical value across all specialties involved in the management of thyroid cancer. It also provides a scholarly overview of the evidence base. (Jayne Franklyn, The New England Journal of Medicine, July, 2006) This is the second edition of an outstanding textbook edited by Leonard Wartofsky and Douglas Van Nostrand. The editors are to be congratulated on bringing together a remarkable array of multidisciplinary authors, who cover every topic pertaining to the clinical management of thyroid cancer. ! Overall, I would highly recommend this book to all practitioners and associated specialties involved in the management of thyroid cancer. The book is clearly and concisely written, well illustrated ! . an excellent textbook. (John Watkinson, Annals of the Royal College of Surgeons of England, Vol. 90, June, 2008) From the reviews ...our present state of knowledge provides clinicians a wide variety of diagnostic and therapeutic modalities to effectively manage this group of cancers. I believe the knowledge contained in this text will give the practicing clinician the necessary information to provide patients the latest and best therapeutic techniques. -Foreword by Ernest L. Mazzaferri, MD This is an excellent comprehensive up-to-date text that is scholarly and complete, yet thoroughly readable. It provides guidance to clinicians and others interested in thyroid cancer based on a combination of a distillate of the published literature [which is fully documented] and the personal experience of the expert author of each chapter...the text reads quickly... I recommend this text to anyone interested in an up-to-date, detailed, clinical guideline to the management of patients with thyroid cancer and the clinical science behind the recommendation. -Journal of Nuclear Medicine This book illustrates the importance of the multidisciplinary approach available in major medical centers for the care of patients with thyroid cancer. The wide-ranging topical nature of this book will interest those working in many fields of medicine. It should be essential reading for trainees in endocrinology, pathology, imaging, nuclear medicine, surgery, and oncology, as well as for specialists in those fields. -The New England Journal of Medicine The book is truly unique and is a critical addition to the contemporary endocrine texts held by general physicians, surgeons, and endocrinologists alike. The book is designed to be a comprehensive guide for clinical management of thyroid cancer and in this regard, is an overwhelming success...One of the most important aspects of this text is the multidisciplinary emphasis provided to all the sub specialists who attend patients with thyroid neoplasms... The book is uniquely organized with several chapters exclusively devoted to the surgical and medical management of individual types of thyroid cancer. This organization is important, because it helps emphasize that each thyroid cancer is unique and not necessarily amenable to one standardized form of treatment...A parallel emphasis of the book is the reliance on evidence-based practice...each chapter is thoroughly referenced, making it easy for the reader to ascertain the original studies on which these conclusions and controversy are based...One of the strengths of this book is the devotion of separate chapters to the management of unique thyroid cancers and unique patients...The text is right up -to- date with regards to the molecular biology of thyroid cancers, the management of medullary thyroid carcinoma, the use of alternative imaging techniques and the use of rhTSH for scanning patients with a history of thyroid cancer...To conclude, this is a unique and important text for all practitioners caring for patients with thyroid cancer. I congratulate the Editor and Authors for their success in detailing this complex and rapidly changing field. ------Trends in Endocrinology and Metabolism ...recommended for anyone who would like a comprehensive reference on the practical aspects of thyroid cancer management. - Head & Neck This comprehensive book brings an instructive review of present knowledge on the pathology, etiology, epidemiology, diagnostic methods and the methods of surgical, radioiodine and chemotherapeutic treatment of various forms of thyroid cancer. Written by outstanding experts and professionally edited by Leonard Wartofsky, it may be considered of substantial utility to all physicians dealing with thyroid diseases. - Endocrine Regulations From the reviews of the second edition: An excellent, truly comprehensive book that covers the etiology, pathogenesis, and clinical management of all forms of thyroid cancer. ! While the book is written clearly enough to be accessible to physicians in training, it will probably be most useful for practicing physicians. The targeted readers include endocrinologists, endocrine surgeons, nuclear medicine specialists, pathologists, and oncologists. ! This is an outstanding textbook ! . surely a work to be added to the library of every clinician taking care of patients with thyroid cancer. (Brian W. Kim, Doody's Review Service, May, 2006) This book includes almost twice as many chapters and contributors as the first edition. I especially enjoyed the addition of patient-focused content, including lists of useful books and Web sites and practical advice regarding radioiodine treatment ! . an excellent, up-to-date book that is of practical value across all specialties involved in the management of thyroid cancer. It also provides a scholarly overview of the evidence base. (Jayne Franklyn, The New England Journal of Medicine, July, 2006) This is the second edition of an outstanding textbook edited by Leonard Wartofsky and Douglas Van Nostrand. The editors are to be congratulated on bringing together a remarkable array of multidisciplinary authors, who cover every topic pertaining to the clinical management of thyroid cancer. ! Overall, I would highly recommend this book to all practitioners and associated specialties involved in the management of thyroid cancer. The book is clearly and concisely written, well illustrated ! . an excellent textbook. (John Watkinson, Annals of the Royal College of Surgeons of England, Vol. 90, June, 2008) Author InformationTab Content 6Author Website:Countries AvailableAll regions |