Overview

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Full Product Details

Author:   Thomas Boehm ,  Yousuke Takahama
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 2014
Volume:   373
Dimensions:   Width: 15.50cm , Height: 0.80cm , Length: 23.50cm
Weight:   2.234kg
ISBN:  

9783662511961

ISBN 10:   3662511967
Pages:   132
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Development and Function of Cortical Thymic Epithelial Cells Kensuke Takada, Izumi Ohigashi, Michiyuki Kasai, Hiroshi Nakase, Yousuke Takahama  Mechanisms of Thymus Medulla Development and Function Graham Anderson, Song Baik, Jennifer E. Cowan, Nicholas I. McCarthy, Kyoko Nakamura, Sonia M. Parnell, Andrea J. White, Peter J. L. Lane, Eric J. Jenkinson and William E. Jenkinson Self-Peptides in TCR Repertoire Selection and Peripheral T Cell Function Wan-Lin Lo and Paul M. Allen Central Tolerance Induction Maria L. Mouchess and Mark Anderson Trafficking to the Thymus Shirley Zhang and Avinash Bhandoola  The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes Hirokazu Tanaka and Ichiro Taniuchi

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