Overview

In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. This book is a collection of reviews of up-to-date information on the above topics by leaders in these fields. This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. These areas of research are prime target areas for drug development by many pharmaceutical and biotechnology companies.

Full Product Details

Author:   Michael E. Maragoudakis ,  Nikos E. Tsopanoglou
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of hardcover 1st ed. 2009
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   0.439kg
ISBN:  

9781441918772

ISBN 10:   1441918779
Pages:   266
Publication Date:   23 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Thrombin: Structure, Functions, and Regulation.- Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation.- Regulation of Thrombin Receptor Signaling.- Thrombin-Activated Protein C: Integrated to Regulate Vascular Physiology.- The Role of Thrombin in Vascular Development.- The Role of Thrombin in Angiogenesis.- Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair.- The Role of Thrombin and Thrombin Receptors in the Brain.- The Role of Thrombin in Tumor Biology.- The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation.- Anti-thrombotic Therapy in Cancer Patients.- Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application.- Novel Anticoagulant Therapy: Principle and Practice.

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