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Author:   Luis M. Botana (University of Santiago de Compostela) ,  Mabel Loza
Publisher:   John Wiley & Sons Inc
Imprint:   John Wiley & Sons Inc
Dimensions:   Width: 16.10cm , Height: 3.10cm , Length: 24.30cm
Weight:   0.844kg
ISBN:  

9780470587195

ISBN 10:   0470587199
Pages:   502
Publication Date:   08 June 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Preface vii Contributors ix 1. cAMP-Specific Phosphodiesterases: Modulation, Inhibition, and Activation 1 R. T. Cameron and George S. Baillie 2. Protease-Activated Receptor 2 37 Qihai Gu and Lu-Yuan Lee 3. Voltage-Gated Sodium Channels as Therapeutic Targets 63 Joshua S. Wingerd, Irina Vetter, and Richard J. Lewis 4. Multitarget Drugs for Stabilization of Calcium Cycling and Neuroprotection in Neurodegenerative Diseases and Stroke 123 Antonio M. G. de Diego, Silvia Lorrio, Jesús M. Hernández-Guijo, Luis Gandía, and Antonio G. García 5. Oligomerization of G-Protein-Coupled Receptors 201 Juan F. López-Giménez and Javier González-Maeso 6. Sigma 1 Receptor Chaperone: Pharmacology and Therapeutic Perspectives 225 Daniel Zamanillo, Enrique Portillo-Salido, José Miguel Vela, and Luz Romero 7. Lipids as New Targets 279 Eduardo Domúnguez 8. Knowledge Base for Nuclear Receptor Drug Discovery 309 Albert A. Antolín and Jordi Mestres 9. Gene Promoters and Transcription Control Regions as Therapeutic Targets 327 Antonio Zorzano, David Sebastian, Jana Sánchez-Wandelmer, Laia Miret, and Fernando Albericio 10. Roles of Glucagon-Like Peptide and Glucose-Dependent Insolinotropic Polypeptide Hormones in Brain Function and Neurodegeneration 351 Christian Hölscher 11. Exocytotic Machinery as a Target for the Development of New Drugs for Schizophrenia 375 María Jose Guerrero, Itsaso Hormaeche, María Uribarri, Julie Masse, and José María Palacios 12. Targeting Epigenetic Abnormalities in the Brain 409 Erin Y. Sterner, Lisa E. Kalynchuk, and Hector J. Caruncho 13. Rodent Models as Tools for Discovering Novel Therapeutic Targets in the Brain: The Case of Epilepsy 427 Justin J. Botterill, Axel J. Guskjolen, Lisa E. Kalynchuk, and Hector J. Caruncho 14. New Approaches Applied to Drug Screening 455 José Brea and María Isabel Loza Index 477

Reviews

In summary, there are a number of well-written and constructed, comprehensive monographs that will be of interest to experts. (ChemMedChem, 1 March 2013) The degree to which an integrated, unified, and visionary perspective emerges across the book is limited. Nonetheless, individual chapters are likely to be very useful to readers in that specific research area. The book certainly offers descriptions of several active target development approaches and application of such approaches in specific biological systems. (Doody's, 1 March 2013)

In summary, there are a number of well-written andconstructed, comprehensive monographs that will be of interest toexperts. (ChemMedChem, 1 March 2013) The degree to which an integrated, unified, and visionaryperspective emerges across the book is limited. Nonetheless,individual chapters are likely to be very useful to readers in thatspecific research area. The book certainly offers descriptions ofseveral active target development approaches and application ofsuch approaches in specific biological systems. (Doody s, 1 March 2013)

In summary, there are a number of well-written and constructed, comprehensive monographs that will be of interest to experts. (ChemMedChem, 1 March 2013) The degree to which an integrated, unified, and visionary perspective emerges across the book is limited. Nonetheless, individual chapters are likely to be very useful to readers in that specific research area. The book certainly offers descriptions of several active target development approaches and application of such approaches in specific biological systems. (Doody's, 1 March 2013)

In summary, there are a number of well-written and constructed, comprehensive monographs that will be of interest to experts. ( ChemMedChem , 1 March 2013) The degree to which an integrated, unified, and visionary perspective emerges across the book is limited. Nonetheless, individual chapters are likely to be very useful to readers in that specific research area. The book certainly offers descriptions of several active target development approaches and application of such approaches in specific biological systems. ( Doody's , 1 March 2013)

Author Information

Luis M. Botana was Director of the Department of Pharmacology at the University of Santiago de Compostela (USC), Director of the European Union Reference Laboratory for Marine Biotoxins, and scientific advisor to the drug company LCIFGA. The author of 200 papers and 15 patents, Dr. Botana is the editor of several other books, including Phycotoxins: Chemistry and Biochemistry, published by Wiley (2007). Mabel Loza is Professor of Pharmacology at the University of Santiago de Compostela (USC). She created the USEF Drug Screening Platform, with more than ten years of experience in public and private mixed early drug discovery programs.

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