Theranostics, Gallium-68, and Other Radionuclides: A Pathway to Personalized Diagnosis and Treatment

Author:   Richard P. Baum, MD ,  Frank Rosch
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Edition:   2012
Volume:   194
ISBN:  

9783642279935


Pages:   578
Publication Date:   23 August 2012
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Theranostics, Gallium-68, and Other Radionuclides: A Pathway to Personalized Diagnosis and Treatment


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Overview

This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics - the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy.

Full Product Details

Author:   Richard P. Baum, MD ,  Frank Rosch
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2012
Volume:   194
Dimensions:   Width: 15.50cm , Height: 3.80cm , Length: 23.50cm
Weight:   1.052kg
ISBN:  

9783642279935


ISBN 10:   3642279937
Pages:   578
Publication Date:   23 August 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

From the contents: Ge-68/Ga-68 generators.- Automation strategies in Ga-68 radiopharmaceutical preparations.- Post-processing via cation exchange cartridges.- Gallium-68 generator integrated system: elution - purification - concentration integration.- Purification and labelling strategies for 68Ga from 68Ge/68Ga generator eluate.- 67Ga and 68Ga purification studies.- The diversity of [68Ga]Ga-based imaging agents.- Nanoparticles and phage display selected peptides for imaging and therapy of cancer.- Click cyclized gallium-68 labeled peptides for molecular imaging and therapy: Synthesis and preliminary in vitro and in vivo evaluation in a melanoma model system.- Early experience with 68Ga-DOTATATE preparation .- 68Ga-radiopharmaceuticals for PET imaging of infection and inflammation.- 68Ga-labeled bombesin analogs for receptor mediated imaging.- A novel 68Ga-labelled pteroic acid-based PET tracer for tumour imaging via the folate receptor.- Measurement of protein synthesis: In vitro comparison of 68Ga-DOTA-puromycin, [3H]tyrosine and 2-fluoro-[3H]tyrosine.- Hypoxia imaging agents labeled with positron emitters.- Lu-177/Y-90 intermediate affinity monoclonal antibodies targeting EGFR and HER2/c-neu: preparation and preclinical evaluation.- Divergent role of 68Ga labeled somatostatin analogs in the work-up of patients with NETs.- Differential uptake of 68Ga-DOTATOC and 68Ga-DOTATATE in PET/CT of gastroenteropancreatic neuroendocrine tumours.

Reviews

From the reviews: The general themes of this book (theranostics and peptide receptor-targeted radiotherapy) derive from evolving successes in the use of generator-produced 68Ga for molecular imaging of disease. ... This book is an excellent resource for investigators interested in gaining a detailed understanding of the state of the art in 68Ga and peptide receptor radionuclide therapy-based theranostics for preclinical and emerging clinical applications. (Michael K. Schultz, The Journal of Nuclear Medicine, Vol. 54 (4), April, 2013)


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