Overview

Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and Disorders The H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer’s disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodegeneration. In light of dramatic advances in research at the molecular level, supported by impressive clinical studies, optimism remains high that an H3 receptor-related drug could hit the market soon. The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders provides a thorough grounding in advances made over the last two decades. It brings together an elite group of 30 pioneering researchers. In writing about their own work, these scientists report on the cutting-edge investigations that are now being conducted across a variety of disciplines. This text is designed to aid researchers and inform those involved in the treatment and clinical aspects of a number of histamine-related diseases. Presents Several Disease-Specific Chapters Certainly, the most comprehensive and cutting-edge volume in the field, this text includes material drawn from groundbreaking research techniques and patent literature. Put together with great thought and passion, it is written to serve as a primary resource for anyone involved with or interested in the identification and localization of H3 receptors and the ligands being developed as therapeutic agents to treat a wide range of diseases including some that were once considered intractable.

Full Product Details

Author:   Divya Vohora
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Weight:   0.453kg
ISBN:  

9780367452513

ISBN 10:   0367452510
Pages:   406
Publication Date:   16 December 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

INTRODUCTION. H3 Receptor Target: Past, Present, and Future Perspectives from Worldwide H3 Experts. The Third Histamine Receptor: From Discovery to Clinics, a Long- Lasting Love Story at INSERM and Bioprojet. Histamine as a Neurotransmitter. THE THIRD HISTAMINE RECEPTOR. Phylogeny, Gene Structure, Expression, and Signaling. Drug Discovery: From Hits to Clinical Candidates. Peripheral Actions and Therapeutic Potential in Periphery. THERAPEUTIC POTENTIAL IN CENTRAL NERVOUS SYSTEM DISORDERS. Cognitive Functions, Attention-Deficit Hyperactivity Disorders, and Alzheimer’s Disease. Sleep Disorders. Obesity. Epilepsy. Schizophrenia. Other Central Nervous System Disorders.

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Vohora, Divya

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