Overview

Telomeres are specialised structures at ends of linear chromosomes. They are involved in a wide range of genetic phenomena ranging from novel biochemistry to a potential role in human ageing and cancer. This book covers a number of diverse subjects including: the role of telomeres in nuclear organisation; telomere DNA sequence and unusual structures formed by telomeric sequences in vitro; replication of telomere sequences by telomerase and how this relates to various DNA sequence features; proteins that bind or interact with telomeres; the role of telomeres in programmed and spontaneous chromosome breakage; recent speculation on the relationship between telomere loss, aging and cancer; telomere position effects on replication and transcription; human telomere structure, genome analysis and genetic disease. This is the first book of its kind to cover this exciting and rapidly expanding field of molecular biology and genetics. It will provide an invaluable teaching tool, and introduction to the subject for newcomers to the field, and also act as an invaluable reference for established researchers.

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9780199636006

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Reviews

In The Telomere Kipling has certainly met, and possibly exceeded, his modest goal of compiling an accessible introduction to a field full of fascinating and unique phenomena ; he has produced an incisive and captivating account with material of interest to a broad spectrum of telophiles, from spectators to central players in research . For a work of nonfiction, I found The Telomere to be a gripping read. Forrest Spencer, Johns Hopkins University, Science, Vol. 269, September 1995 Although there are a number of good up-to-date review articles on particular aspects of telomeres, this book represents the first attempt that I have come across to cover such a breadth of telomere topics in a comprehensive manner. The result is excellent ... a superb source of material for anybody already in the telomere field or thinking of moving into it. In summary, I think that this is an excellent piece of academic writing and I would certainly spend GBP45.00 to own it. Alistair Chambers, University of Nottingham, Heredity 77 (1996) an excellent little book ... a very timely introduction to the telomere mystery ... Thoroughly recommended and cheap at the price in paperback. Eric Reeve, University of Edinburgh, Genetical Research, Vol. 67 - 1996

Kipling employs a broad selection and insightful discussion of current reviews and primary references to introduce the reader to telomeres. . .those new to this specialized area will appreciate the author's knowledgeable evaluation of how well the research cited supports certain models of telomere behavior. --Choice (Kipling) has produced an incisive and captivating account with material of interest to a broad spectrum of telophiles, from spectators to central players in research....The Telomere is rigorous in summary, bold in speculation, and near comprehensive in scope....a gripping read. --Science

`In The Telomere Kipling has certainly met, and possibly exceeded, his modest goal of compiling an accessible introduction to a field full of fascinating and unique phenomena ; he has produced an incisive and captivating account with material of interest to a broad spectrum of telophiles, from spectators to central players in research . For a work of nonfiction, I found The Telomere to be a gripping read.' Forrest Spencer, Johns Hopkins University, Science, Vol. 269, September 1995 `Although there are a number of good up-to-date review articles on particular aspects of telomeres, this book represents the first attempt that I have come across to cover such a breadth of telomere topics in a comprehensive manner. The result is excellent ... a superb source of material for anybody already in the telomere field or thinking of moving into it. In summary, I think that this is an excellent piece of academic writing and I would certainly spend GBP45.00 to own it.' Alistair Chambers, University of Nottingham, Heredity 77 (1996) `an excellent little book ... a very timely introduction to the telomere mystery ... Thoroughly recommended and cheap at the price in paperback.' Eric Reeve, University of Edinburgh, Genetical Research, Vol. 67 - 1996

<br> Kipling employs a broad selection and insightful discussion of current reviews and primary references to introduce the reader to telomeres. . .those new to this specialized area will appreciate the author's knowledgeable evaluation of how well the research cited supports certain models of telomere behavior. --Choice<br> (Kipling) has produced an incisive and captivating account with material of interest to a broad spectrum of telophiles, from spectators to central players in research....The Telomere is rigorous in summary, bold in speculation, and near comprehensive in scope....a gripping read. --Science<br>

Kipling employs a broad selection and insightful discussion of current reviews and primary references to introduce the reader to telomeres. . .those new to this specialized area will appreciate the author's knowledgeable evaluation of how well the research cited supports certain models of telomere behavior. --Choice<br> (Kipling) has produced an incisive and captivating account with material of interest to a broad spectrum of telophiles, from spectators to central players in research....The Telomere is rigorous in summary, bold in speculation, and near comprehensive in scope....a gripping read. --Science<br>

<br> Kipling employs a broad selection and insightful discussion of current reviews and primary references to introduce the reader to telomeres. . .those new to this specialized area will appreciate the author's knowledgeable evaluation of how well the research cited supports certain models of telomere behavior. --Choice<p><br> (Kipling) has produced an incisive and captivating account with material of interest to a broad spectrum of telophiles, from spectators to central players in research....The Telomere is rigorous in summary, bold in speculation, and near comprehensive in scope....a gripping read. --Science<p><br>

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