Overview

A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE

Full Product Details

Author:   Hans-Joachim Gabius (Ludwig-Maximilians-University of Munich, Germany)
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Blackwell Verlag GmbH
Dimensions:   Width: 17.80cm , Height: 3.30cm , Length: 24.60cm
Weight:   1.252kg
ISBN:  

9783527320899

ISBN 10:   352732089
Pages:   597
Publication Date:   23 September 2009
Audience:   College/higher education ,  Postgraduate, Research & Scholarly ,  Undergraduate
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

"CHEMICAL BASIS The Biochemical Basis and Coding Capacity of the Sugar Code (Rudiger, Gabius) Three-dimensional Aspects of the Sugar Code (Kozar, Andre, Ulicny, Gabius) The Chemist's Way to Synthesize Glycosides (Oscarson) The Chemist's Way to Prepare Multivalency (Chabre, Roy) Analytical Aspects: The Analysis of Protein-Bound Glycans (Nakagawa) NATURAL GLYCOSYLATION - GLYCOPROTEINS N-Glycosylation (Zuber, Roth) O-Glycosylation: Structural Diversity and Functions (Patsos, Corfield) Glycosylation of Model and ""Lower"" Organisms (Wilson, Paschinger, Rendic) Glycosylphosphatidylinositol Anchors: Structure, Biosynthesis and Functions (Shams-Eldin, Debierre-Grockiego, Schwarz) NATURAL GLYCOSYLATION - GLYCOLIPIDS, PROTEOGLYCANS, CHITIN Glycolipids (Kopitz) Proteoglycans (Buddecke) Chitin (Merzendorfer) PROTEIN-CARBOHYDRATE INTERACTIONS Protein-Carbohydrate Interactions: Basic Concepts and Methods for Analysis (Solis, Romero, Menendez, Jimenez-Barbero) How to Determine Specificity: From Lectin Profiling to Glycan Mapping and Arrays (Tateno, Kuno, Hirabayashi) The History of Lectinology (Rudiger, Gabius) Ca2+: Mastermind and Active Player for Lectin Activity (Including a Gallery of Lectin Folds) (Gabius) Bacterial and Viral Lectins (Holgersson, Gustafsson, Gaunitz) Plant Lectins (Rudiger, Gabius) Animal and Human Lectins (Gabius) Routes in Lectin Evolution: Case Study on the C-Type Lectin-Like Domains (Gready, Zelensky) Carbohydrate-Carbohydrate Interactions (Bucior, Burger, Fernandez-Busquets) BIOMEDICAL ASPECTS AND CASE STUDIES Diseases of Glycosylation (Hennet) Animal Models to Delineate Glycan Functionality (Honke, Taniguchi) Glycobiology of Fertilization and Early Embryonic Development (Habermann, Sinowatz) Glycans as Functional Markers in Malignancy? (Andre, Kopitz, Kaltner, Villalobo, Gabius) Small is Beautiful: Mini-Lectins in Host Defense (Lehrer) Inflammation and Glycosciences (Schwartz-Albiez) Sugars as Pharmaceuticals (Osborn, Turkson) Platelet Glycoproteins as Lectins in Hematology (Hoffmeister, Falet) Neurobiology meets Glycosciences (Ledeen, Wu) COMPANION WEB-SITE: www.wiley-vch.de/home/thesugarcode"

Reviews

“In summary, this ambitious book is a must-have for every library collection on carbohydrates and a great resource for chemistry and biology students curious for an entry into the rapidly growing area of glycosciences. The decoding process has just begun. (ChemBioChem, 2010)

Author Information

Hans-Joachim Gabius obtained his Ph.D. in 1982 at the Max-Planck-Institute for Experimental Medicine in Gottingen. After doing post-doctoral research from 1984-1985 in the group of S. H. Barondes at the UC San Diego, he was appointed first as assistant professor for biochemistry at the Max-Planck-Institute for Experimental Medicine in Gottingen (1987) and then as associate professor for pharmaceutical chemistry at the University of Marburg (1991). Since 1993 he is heading the Institute for Physiological Chemistry, Faculty of Veterinary Medicine at the University of Munich. Prof. Gabius received numerous research awards including the Otto-Hahn-Medal (1983), the Award of the Dr. Carl-Duisberg-Foundation (1988) and the Award of the Paul-Martini-Foundation (1990). His research interests are focused on chemical, biophysical and biochemical analysis of protein - carbohydrate interactions with biomedical relevance, such as the development of glycoscientific strategies for tumor diagnosis and therapy and the elucidation of functions of mammalian lectins. His research led to a prominent placement in the ISI ranking of highly cited papers in 1998.

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