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Author:   Ernst Bamberg ,  Wilhelm Schoner
Publisher:   Steinkopff Darmstadt
Imprint:   Steinkopff Darmstadt
Weight:   1.660kg
ISBN:  

9783798509610

ISBN 10:   3798509611
Pages:   926
Publication Date:   31 December 1994
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Gene organization, analysis of the sodium pump by molecular biology.- Transcription factors regulating the Na+/K+-ATPase genes.- Expression of functional Na+/K+-ATPase in yeast.- Expression of functional Na+/K+-ATPase in insect cells using baculovirus.- Sp1 and an E-box binding protein regulate Na+/K+-ATPase ?2-subunit gene.- Cloning and analysis of the 5?-flanking region of the rabbit Na+/K+-ATPase al subunit gene.- Positive and negative transcriptional elements in the chicken Na+/K+-ATPase ?1-subunit gene.- Transcriptional regulation of the Na+/K+-ATPase al gene expression by 8-bromo-cyclic AMP in renal cells.- Cloning of the dog Na +/K + ATPase al-subunit.- Cloning and characterization of a new member of the family of Na +/K+-ATPase genes.- The cloning of homologous Na+/K+-ATPase genes from new species.- Functional expression of the gastric H, K-ATPase in Xenopus oocytes.- Over-expression of the peptide containing the ATP-binding site in Na +/K+-ATPase ?-subunit.- Expression of Na+/K+-ATPase in Saccharomyces cervisiae.- Regulation of Na+/K+-ATPase al and ?1 expression in epithelial cells.- The ?-subunit of the Na+/K+-ATPase has catalytic activity independent of the ss-subunit.- Functional expression of Na+/K+-ATPase a and ? isoforms.- Ca2+/cahnoduIin-sensitive Na+/K+-ATPase activity expressed in chimeric molecules between the plasma membrane Ca2+-ATPase and the Na +IK+-ATPase a-subunit.- Expression of Na+/K+-ATPase and H+/K+-ATPase fusion proteins Sf-9 insect cells.- In vitro synthesis of H+/K+-ATPase polypeptides in insect cells using the baculovirus expression system.- Molecular biology and structure of the calcium pump of sarcoplasmic reticulum.- Functional domains of sarcoplasmic reticulum Ca2+-ATPase studied by site-directed mutagenesis.- Conservation patterns define interactions between transmembrane helices of P-type ion pumps.- Structural studies of Ca2+-ATPase by cryoelectron microscopy.- The topology of sarcoplasmic Ca2+-ATPase and Na+/ K+-ATPase in the M5/M6 region.- Changes of molecular structure and interaction in the catalytic cycle of sarcoplasmic reticulum Ca2+-ATPase. Infrared difference spectra of Ca2+-binding, nucleotide binding, phosphorylation and phosphoenzyme conversion.- Ca2+-binding to sarcoplasmic reticulum Ca2+-ATPase in the absence of chelators.- Electrogenicity and countertransport properties of reconstituted sarcoplasmic reticulum Ca2+-ATPase.- Cell Biology.- Endo-exocytotic sorting of Na+/K+-pumps in developing oocytes and embryos of Xenopus laevis.- Determinants of cell surface distributions of Na+/K+-ATPase in polarized epithelial cells.- Physiologic relevance of the ?2 isoform of Na+/K+-ATPase in muscle and heart.- Na+/K+-ATPase of neurons and glia.- Expression of a truncated ? subunit of the Na+/K+-ATPase (?-1-T) in smooth muscle cells.- The C-terminus of Na+/K+-ATPase ss-subunit contains a hydrophobic assembly domain.- Synthesis and secretion of the extracellular domain of the ss1 subunit isoform of Na +/K+-ATPase into the culture medium of CHO cells.- The amino-terminal transmembrane region of the ? subunit is important for Na +/K+-ATPase complex stability.- Construction and expression of chimeric cDNAs of Na+/K+- and H+/K+-ATPase ?-subunits.- Segregation of maternal Na+/K+-pump al and ss3 mRNAs to animal blastomeres of early Xenopus embryos.- Isoform specific antisera for the Na+/K+-ATPase ssl and ss2 subunits: Localization in fetal rat tissues.- Polyclonal antibodies to extramembrane domains of Na+/K+-ATPase ?l and ?3 isoforms.- Differential axonal transport of individual Na+/K+-ATPase ? subunit isoforms in rat sciatic nerve.- Differential expression of Na+/K+-ATPase isoforms in cultured rodent cardiac and skeletal muscle cells.- Na+/K+-ATPase abundance and activity in HeLa cells transfected with rat ? isoforms.- Aldosterone induces a delayed parallel increase in total and cell-surface Na+/K+-ATPase in A6 kidney cells.- Differential aldosterone effects on two epithelial cell pools of [3H]ouabain binding sites.- Branchial Na+/K+-ATPase expression in the European eel (Anguilla anguilla) following saltwater acclimation.- Differentiation of Na+/K+-ATPase by digoxigenin-labeled lectins on blots. Evidence for organ-typical glycoforms.- Structure and reaction mechanisms of the sodium pump.- Structural requirements for the interaction between the Na+/K+-ATPase ?- and ?-subunits.- Structure and function of ion pumps studied by atomic force microscopy and gene-transfer experiments using chimeric Na+/K+- and Ca2+-ATPases.- Na+/K+-ATPase: Cardiac glycoside binding and functional importance of negatively charged amino acids of transmembrane regions.- Functional analysis of the disulfide bonds of Na+/K+-ATPase ?-subunit by site-directed mutagenesis.- Purified renal Na+/K+-ATPase; subunit structure and structure-function relationships of the N-terminus of the al-subunit.- Organization of the cation binding domain of the Na+/K+-pump.- The stabilization of cation binding and its relation to Na+/K+-ATPase structure and function.- Is the sodium pump a functional dimer.- Atomic force microscopy of crystallized Na+/K+-ATPase.- Scanning force microscopical studies of the Na+/K+-ATPase.- Molecular imaging of purified Na+/K+-ATPase molecules in canine kidney membranes using atomic force microscopy.- Cytoplasmic and extracellular domains in two-dimensional crystals of Ma+/K+-ATPase.- Membrane topology of the a subunit of Na+/K+-ATPase.- Identification of epitopes recognized by Na+/K+-ATPase-directed antibodies.- Probing the ?-subunit folding by dot-sandwich immunochemical analysis.- Determination of sidedness of COOH-terminus of Na+/K+-ATPase ?-subunit by vectorial labeling.- Approaches to disulfide bonds identification in the Na+/K+-ATPase ?-subunit.- Is the cysteine104 part of the sugar binding subsite of the cardiac glycoside receptor of Na +/K+-ATPase.- Towards understanding the molecular mechanism of the inhibitory cardiac glycoside interaction with the receptor enzyme Na+/K+-transporting ATPase.- Palytoxin induces K + release from yeast cells expressing Na+/K+-ATPase.- Bafilomycin and concanamycin derivatives as specific inhibitors of P- and V-type ATPases.- Tertiary amines as cytosolic K+-antagonists of gastric H+/K+-ATPase.- Probing the cation binding site of Na+/K+-ATPase with competitive Na + antagonists.- Structure of the cation occlusion domain of Na+/K+-ATPase studied by proteolysis, interaction with Ca2+ ions and thermal denaturation.- Functional consequences of alterations to Glu329 and other residues in the transmembrane sector of Na+/K+-ATPase.- Identification of Glu779 as an essential part of the cation binding site of the sodium pump.- Rearrangements of the membrane-associated segments of Na+/K+-ATPase upon phosphorylation, ion-occlusion and ouabain binding.- Na+/K+-ATPase: Regulation of K+ access channels by K+.- The ribose conformation of ATP affects the kinetic properties of Na+/K+-ATPase.- ATP accelerates phosphorylation of the Na+/K+-ATPase acting with low apparent affinity.- Effects of ATP on the steady-state level of the phosphoenzyme of pig kidney Na+/K+-ATPase.- A phase-change model of transient kinetics of phosphoenzyme of Na+/K+-ATPase.- The E2 conformation of Na+/K+-ATPase during the Na+-ATPase activity.- Parallel pathway models for electric organ Na+- and Na+/K+-ATPases.- Enzymic activities of solubilized and dissociated (? + ?) chains and of soluble ?? protomers of pig kidney Na+/K+-ATPase.- One phosphorylation site per ??-protomer in reconstituted shark Na+/K+-ATPase.- Protomer association of solubilized Na+/K+-ATPase induced by ATP.- Arginine appears not to be located in the active site of Na+/K+-ATPase.- Does the ?-subunit of the red cell membrane Na+/K+-ATPase exist as a homodimer.- Functional diversity of tissue-specific Na+/K+-pumps delivered from exogenous sources into erythrocytes.- Two-sided bi-directional Na+/K+-ATPase-liposomes. Structure and function.- Electrogenicity and voltage dependence.- Voltage sensitivity of the Na+/K+ pump: Structural implications.- Electrogenic properties of the endogenous and of modified Torpedo Na+/K+-pumps in Xenopus oocytes: The access channel for external cations.- Electrogenic and electroneutral partial reactions in Na+/K+-ATPase from eel electric organ.- Flexibility and constraint in the interpretation of Na +/K + pump electrogenicity: What is an access channel.- Partial reactions in Na+/K+- and H+/K+-ATPase studied with voltage-sensitive fluorescent dyes.- Changes of membrane capacitance coupled with electrogenic transport by the Na+/K+-ATPase.- Reversal potential of Na + pump current in cardioballs at various ?G of ATP hydrolysis.- Characteristics of sodium pump current in guinea-pig and rat dorsal root ganglion neurons.- Kinetic analysis and voltage dependency of ?-3 Na+/K+-pump.- Access channel model for Na + and K + translocation by the Na+/K+-pump.- Na+/K+-pump mutant with a slow charge translocating step.- Analyzing the Na+/K+-pump in outside-out giant membrane patches of Xenopus oocytes.- The role of putative intramembraneous glutamic acid residues of the ?-subunit of the sodium pump in external cation binding.- Conformational states of Na+/K+-ATPase probed with RH-421 and eosin.- Do lipophilic anions affect the spatial organization of the ATP binding site of the Na+/K+-ATPase.- Na+/K+-ATPase: Probing for a high affinity binding site for Na+ by spectrofluorometry.- Interaction between cytoplasmic sodium binding sites and cardiotonic steroids.- Dielectric coefficients of the extracellular release of sodium ions.- Spectroscopy as a tool in Na+/K+-ATPase.- Changes in the conformational state of probe-labeled Na+/K+-ATPase in real time.- Mechanism of the conformational change in fluorescein 5? -isothiocyanate-modified Na +/K+-ATPase.- Relaxation spectroscopy applied to determination of rate constants for ligand binding and dissociation.- Does eosin treat all P-type ATPases equally.- Kinetic analyses of conformational changes and charge transfer by Na+/K+-ATPase.- Reassignment of cation-induced population of main conformational states of FITC-Na+/K+-ATPase as detected by fluorescence spectroscopy and characterized by equilibrium binding studies.- Caged Na + and K + ligands: Photochemical properties, application for membrane transport studies and selective fluorimetric detection of alkali ions.- Kinetic and spectroscopic characterization of the cardiac glycoside binding site of Na+/K+-ATPase employing a dansylated ouabain derivative.- Kinetics and mechanism of cation-binding to Na+/K+-ATPase.- Comparison of E1 and E2 conformers of membrane bound Na+/K+-ATPase using time-resolved phosphorescence anisotropy measurements.- Application of time-resolved phosphorescence anisotropy measurements for the study of rotational mobility of eosin-labeled Na+/K+-ATPase and Ca2+-ATPase.- Pyridoxal-5?-phosphate probe at Lys 480 can monitor conformational events induced by acetyl phosphate in Na+/K+-ATPase.- Phosphorylation of Na+/K+-ATPase by p-nitrophenylphosphate and other phosphatase substrates.- Estimation of distance changes between Cys-964 and Lys-501 in Na+/K+-ATPase intermediates and the orientation of transmembrane segment containing Cys 964.- Hormonal regulation of the sodium pump.- Heterogeneity of distribution and of the regulation by corticosteroids of transport ATPases along the rat collecting tubule.- Hormonal regulation of Na+/K+-ATPase activity.- Regulation of the Na+/K+-pump by insulin.- Phosphorylation of Na+/K+-ATPase by protein kinases: structure-functions relationship.- Stimulation by phorbol 12-myristate 13-acetate (PMA) of Na+/K+-pump mediated 86Rb+-influx into human lymphocytes.- Regulation of the sodium pump by fatty acids and acylglycerols.- Relations of Na+/K+-pump kinetics to polyunsaturated molecular species of plasmalogen-phosphatidylethanolamine in intact human erythrocytes.- Inhibitory actions of monoclonal antibody to phosphatidylserine on Na+/K+-ATPase.- Regulation of sodium pump with physiologically active ligands (prostaglandins, galanin).- Characterization of the molecular isoforms of Na+/K+-ATPase subunits along the rat nephron by polymerase chain reaction.- Increase in Na pump activity of brain-type isoforms via increased turnover rate after glutamate excitation of cerebral neurons.- The ?3 isoform protein of the Na+/K+-ATPase is associated with the sites of neuromuscular and cardiac impulse transmission.- Direct correlation of Na+/K+-ATPase-isoform abundance and myocardial contractility in mouse heart.- Endogenous digitalis-like substances.- Discovery of endogenous ouabain - a new mammalian hormone.- Structure and biological activity of the Na+/K+-ATPase inhibitor isolated from bovine hypothalamus: Difference from ouabain.- Identification and physiological significance of Na+/K+-pump inhibitors in rats.- Endogenous digitalis-like factor from umbilical cord and ouabain: Comparision of biochemical properties.- New steroidal digitalis-like compounds in human cataractous lenses.- Large scale purification of an endogenous Na+/K+-pump inhibitor from bovine adrenal glands.- Demonstration of inhibitors of the sodium pump in human plasma and bovine adrenals cross-reacting with proscillaridin A antibodies.- A labile endogenous Na-pump inhibitor in man.- Ouabain-like immunoreactivity in the brain and the adrenal medulla is increased in DOCA-salt hypertensive rats.- Changes in the endogenous ouabain-like substance in the brain and cerebrospinal fluid after cold-induced vasogenic brain edema.- Modulation of the Ca2+/Mg2+-ATPase activity of synaptosomal plasma membrane vesicles by the hypothalamic hypophysary Na+/K+-ATPase inhibitory factor (HHIF).- Endogenous digitalis in acute myocardial ischemia.- Role of P-type ATPases in disease.- Sensitivity of the failing and nonfailing human heart to cardiac glycosides.- Autoimmune gastritis and H+/K+-ATPase.- Na + modulation of K+ transport by Na+/K+-pump in red eells of salt-sensitive and salt-resistant Dahl rats.- Biochemical characterization of the Na+/K +-ATPase isoforms in human heart.- The canine cardiac ?3 isoform of Na+/K+-ATPase is highly sensitive to digitoxigenin.- Heterogeneous Na+ sensitivities of Na+/K+-ATPase isoenzymes in membranes; modulation by anaesthesia and diets.- Na+/K+-ATPase isoforms in human heart; variation with mammalian species and pathophysiological states.- Non effectiveness of ouabain and decrease in Na+/K+-ATPase affinity for ouabain in failing rabbit heart.- Digoxin treatment and congestive heart failure in light of human cardiac and skeletal muscle digitalis glycoside receptor studies.- Age-related changes in Na+/K+-ATPase and Ca2+-ATPase concentration in rat heart ventricle.- Digoxin induced dysfunction of skeletal muscle potassium homeostasis during exercise.- Na+/K+-ATPase isoform expression in cardiac muscle from Dahl salt-sensitive and salt-resistant rats.- Na+/K+-ATPase from spontaneously hypertensive rats.- Na+/K+-pump ?3 isoform in rat vascular smooth muscle and its physiological role.- Hormonal effects on the expression of Na+/K+-ATPase ?-subunit during pregnancy.- Does human skeletal muscle Na+/K+-ATPase concentration correlate with capacity for muscle performance.- Regulation of the Na+/K+-pump proteins in skeletal muscle: Acute effects of insulin on ?2 distribution and muscle fibre-type specific expression of ? subunits.- Insulin as regulator of skeletal muscle Na+/K+-ATPase concentration in rats with experimental diabetes and patients with diabetes mellitus.- The maximum capacity for active sodium-potassium transport in the slow and fast skeletal muscle of obese (ob/ob) and lean mice.- Alterations in Na+/K+-ATPase isoforms of different tissues in streptozotocin induced diabetes mellitus.- Properties of the oxidized Na+/K+-ATPase.- Modification of Na+/K+-ATPase in a model of epilepsy in the rat.- Tumor development and changes in Na+/K+-pump parameters.- Distinct interaction of mercury and silver with isolated Na+/K+-ATPase.- Author index.

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