Overview

It is well established that glial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. The Role of Glia in Neurotoxicity brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function. This book explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity. This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity. This timely review not only presents an excellent overview of the state of the science but also provides direction for future research into the consequences of an altered glial-neuronal unit.

Full Product Details

Author:   Michael Aschner (Vanderbilt University, Nashville, Tennessee, USA) ,  Harold K. Kimelberg (Albany Medical College)
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 15.60cm , Height: 2.10cm , Length: 23.50cm
Weight:   0.771kg
ISBN:  

9780849347924

ISBN 10:   0849347920
Pages:   384
Publication Date:   27 March 1996
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Replaced By:   9780849317941
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

The Role of Microglia in Neurotoxic Injury, W.J. Streit Role of Radial Glia in Neurotoxic Injury, B.H. Choi Responses of Oligodendrocytes to Neurotoxins, J.deVellis Schwann Cells and Their Potential Involvement in Neurotoxic Expression, R.M. LoPachin and E.J. Lehning Astroglial Responses to Neurotoxins, M.D. Norenberg Responses of Glia to Alcohol, A.K. Snyder Astrocytes and Ammonia Neurotoxicity, J. Albrecht Manganese Neurotoxicity, F.C. Wedler Lead Neurotoxicity, E. Tiffany-Castiglioni Metallothioneins, and Physiological and Pathological Consequences of Methylmercury Accumulation in Astrocytes, M. Aschner Mechanisms of Glial-Mediated Cadmium and Zinc Neurotoxicity, T. Jalonen MPTP Neurotoxicity, W. Nicklas Quinolinic Acid Neurotoxicity, R. Schwarcz Nitric Oxide-Induced Glial Toxicity, J. Merrill and S. Murphy Gene Expression in Astrocytes after Neural Injury, P.M. Martin and J.P. O'Callaghan Effects of Toxins on Glia in Relation to Vasogenic and Cytotoxic Edema, H.K. Kimelberg, D. Vitarella, and M. Aschner Precursor Synthesis and Neurotransmitter Uptake by Astrocytes as Targets of Neurotoxicants, D.L. Martin and R.A. Waniewski

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