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Author:   Thomas Unger (MD, PhD, Professor & Scientific Director, CARIM School for Cardiovascular Diseases, Maastricht University, The Netherlands) ,  U. Muscha Steckelings (MD, PhD, Associate Professor, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark) ,  Robson Augusto Souza dos Santos (MD, PhD, Professor, Federal University of Minas Geriais, Minas Geriais, Brazil)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 21.60cm , Height: 1.50cm , Length: 27.60cm
Weight:   0.860kg
ISBN:  

9780128013649

ISBN 10:   0128013648
Pages:   316
Publication Date:   23 April 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part I: The AT2 Receptor Introduction The AT2 receptor: from enigma to therapeutic target AT2 receptor detection by selective ligands Basic mechanisms and signaling Animal models with a genetic alteration of AT2 expression AT2 signaling: resolved and unresolved AT1-AT2 crosstalk (Patho)-physiological effects of AT2R stimulation AT2R in Myocardial infarction and congestive heart failure AT2R, vascular effects, blood pressure effects                              AT2R in neuroprotection and -regeneration AT2R and cognitive function AT2R in kidney disease AT2R and natriuresis AT2R and vascular remodeling AT2R and inflammation AT2R, ATIP and cancer AT2R and sympathetic outflow Metabolic effects of AT2R stimulation Gender differences in AT2R expression and actions Future clinical application Discovery of non-peptide selective AT2R agonists Synthesis of peptide AT2 agonists Potential future clinical indications for AT2-agonists Part II: MAS Receptor / Ang(1-7) / ACE-2: Introduction The Mas Story Basic mechanisms and signaling Animal models with a genetic alteration of ACE2/MAS MAS signaling: resolved and unresolved MAS dimerisation and MAS/AT2 crosstalk Basic aspects of ACE-2 regulation and function (Patho)-physiological effects of MAS stimulation MAS in Myocardial infarction and congestive heart failure MAS, vascular effects, blood pressure effects                              MAS in neuroprotection and -regeneration MAS and cognitive function MAS in the kidney

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