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OverviewOur knowledge about the function of the melanocyte has expanded beyond boundaries not previously imagined. The melanocyte is no longer considered merely a factory for the production of the pigment melanin. Old data do not contradict the new but must be reinterpreted in light of modern concepts of molecular and cellular biology, enzymology, biochemistry, chemistry, and physics. Diseases of the pigmentary system must be understood in terms of modern science. The editors, each with special knowledge of the pigmentary system, have combined their expertise and talents to produce a book that will serve as the ultimate resource for the study of all aspects of pigment cell biology. There is no comprehensive, scholarly reference available which compiles both old and new data into a single source. This book fills that void. There are monographs to assist dermatologists caring for individuals with disorders of pigmentation, and textbooks with an introductory chapter on the physiology of pigmentation and a clinical chapter on the disorders manifested by common abnormalities of the pigmentary system. These resources continue to be invaluable, however they are written for a specific type and level of audience. This volume is encyclopedic in scope, so that the biologist, chemist, cosmetic scientist, and clinician, whether novice or sophisticated expert, can peruse any section of the book with confidence that it contains most of the worlds knowledge on pigmentation, including historical work. The bibliographies are also prepared to be as comprehensive and all-inclusive as possible. The first part of the book brings together the molecular and cellular biology, biochemistry, chemistry, physics, and physiology of the normal melanocyte as known in the 1990s. The second part continues this theme, presenting a comprehensive discussion of most disorders of pigmentation described to date. Information about pathophysiology, treatment and other clinical data is included. The goal of the editors is to provide the ultimate reference for practicing physicians who care for patients with the rarest or most common disorders of pigmentation, the laboratory scientist studying disease in order to help the study of basic processes which affect the pigmentary system, and the cosmetic scientist who seeks comprehensive information on the pharmacopoeia available for treating pigmentary disorders. All specialists interested in some aspect of the pigmentary system can seek current answers to questions related to their work. Full Product DetailsAuthor: James J. Nordlund (Professor and Chairman of the Department of Dermatology, Professor and Chairman of the Department of Dermatology, University of Cincinnati College of Medicine, USA) , Raymond E. Boissy (Associate Professor of Dermatology, Associate Professor of Dermatology, University of Cincinnati, USA) , Vincent J. Hearing (Senior Investigator, Laboratory of Cell Biology, Senior Investigator, Laboratory of Cell Biology, National Cancer Institute) , Richard King (Professor of Genetics, Professor of Genetics, University of Minnesota, USA)Publisher: Oxford University Press Inc Imprint: Oxford University Press Inc Dimensions: Width: 35.30cm , Height: 7.40cm , Length: 23.60cm Weight: 3.572kg ISBN: 9780195098617ISBN 10: 0195098617 Pages: 1106 Publication Date: 21 May 1998 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand ![]() We will order this item for you from a manufactured on demand supplier. Table of Contents41: Metabolic, Nutritional & Endocrine Disorders 42: Chemical, Pharmacologic & Physical Agents Causing Hypomelanoses 43: Infectious Hypomelanoses 44: Inflammatory Hypomelanoses 45: Neoplastic Hypomelanoses 46: Miscellaneous Hypomelanoses: Disorders Characterized by Depigmentation 47: Miscellaneous Hypomelanoses: Disorders Characterized by Hypopigmentation 48: Miscellaneous Hypomelanoses: Disorders Characterized by Extracutaneous Loss of Pigmentation 49: Hypopigmentation without Hypomelanosis Section 7: Disorders of Hyperpigmentation 50: Genetic Epidermal Syndromes: Disorders Characterized by Generalized Hyperpigmentation 51: Genetic Epidermal Syndromes: Disorders Characterized by Reticulated Hyperpigmentation 52: Genetic Epidermal Syndromes: Disorders Characterized by Cafe au Lait Macules 53: Genetic Epidermal Syndromes: Disorders Characterized by Lentigines 54: Genetic Epidermal Syndromes: Disorders Characterized by Localized Hyperpigmentation 55: Genetic Epidermal Syndromes: Disorders of Hyperpigmentation and Premature Aging 56: Congenital Epidermal Hypermelanoses 57: Acquired Epidermal Hypermelanoses 58: Acquired & Congenital Dermal Hypermelanoses 59: Mixed Epidermal & Dermal Hypermelanoses 60: Drug Induced or Related Pigmentation 61: The Melanocyte System of the Nails and its Disorders 62: Rare Benign Neoplasm Section 8: Treatment of Pigmentary Disorders 63: Topical Treatment of Pigmentary Disorders 64: Phototherapy Pigmentary Disorders 65: Sunscreens and Cosmetics 66: Surgical Treatment of Pigmentary Disorders 67: Laser Treatment of Pigmentary Disorders Part I: THE PHYSIOLOGY OF THE PIGMENTARY SYSTEM Section 1: Historical & Comparative Perspectives of the Pigment System 1: A History of the Science of Pigmentation 2: Comparative Anatomy & Physiology of Pigment Cells in Nonmammalian Tissues Section 2: The Morphology, Distribution & Biology of the Pigment Cell 3: General Biology of Mammalian Pigmentation 4: Extracutaneous Melanotcytes 5: Regulation of Melanoblast Migration & Differentiation 6: Biogenesis of Melanosomes 7: Melanosomal Translocation and Transfer 8: Human Pigmentation & Regulation 9: Melanocyte Interactions in the Skin 10: Growth Factor Receptors and Signal Transduction Regulating the Proliferation & Differentiation of Melanocytes 11: Aging, Replicative Senescence and the Differentiated Function of the Melanocyte 12: Advances in Long Term Maintenance of Normal Human Melanocytes in Culture 13: Advances in Immortalization of Cultured Melanocytes and Melanoblasts 14: Advances in Melanogenic Assays and Subcellular Fractionation 15: Melanocyte Stimulating Hormone (MSH) and the MSH Receptor Section 3: The Molecular Biology of the Pigment Cell 16: Molecular Approach to the Study of Pigment Cells 17: Piebaldism, Waardenburg Syndrome, and Related Genetic Disorders - Molecular & Genetic Aspects 18: Anatomy of Pigment Cell Genes Acting at the Cellular Level 19: Anatomy of Pigment Cell Genes Acting at the Subcellular Level 20: Genetic Regulation of the Pigment Cell 21: Advances in Transgenic Animal Models 22: Advances in In Vitro Gene Expression 23: Advances in Gene Mapping Section 4: Chemistry & Physics of Melanin and Enzymology of Melanin Synthesis 24: The Chemistry of Melanins and Related Metabolites 25: The Physical Properties of Melanins 26: The Photobiology of the Tanning Response 27: The Toxicology & Pharmacology of Melanins 28: The Enzymology of Melanogenesis 29: Mechanisms of Inhibition of Melanin Pigmentation 30: The Regulation of Melanin Formation 31: Advances in Chemical Analysis of Melanins 32: Advances in Physical Analysis of Melanins 33: Advances in Enzymatic Analysis of Melanogenesis Part II: THE PATHOPHYSIOLOGY OF THE PIGMENTARY SYSTEM Section 5: An Overview of Human Skin Color and its Disorders 34: The Normal Color of Human Skin 35: Mechanisms that Cause Abnormal Skin Color Section 6: Disorders of Hypopigmentation and Depigmentation 36: Genetic Hypomelanoses: Disorders Characterized by Congenital Depigmentation 37: Genetic Hypomelanoses: Disorders Characterized by Acquired Depigmentation 38: Genetic Hypomelanoses: Disorders Characterized by Generalized Hypomelanosis 39: Genetic Hypomelanoses: Disorders Characterized by Locilized Hypomelanosis 40: Genetic Hypomelanoses: Disorders Characterized by Hypopigmentation of the HairReviewsThis book is the first comprehensive treatise on pigmentation that combines its physiology in animals with its pathophysiology and clinical aspects in humans. The five editors have provided an opportunity for the leading investigators in pigmentation to show their stuff. The editors and authors have succeeded in presenting a thorough work. --The New England Journal of Medicine Ihe Pigmentary System: Physiology and Pathophysiology is a large, current, comprehensive and much needed text bringing together practically all aspects of normal pigment cell biology and ean extremely detailed presentation of most pigmentary disorders. The five editors, all well known in the pigment field, have brought together 104 other contributors to produce a pigment encyclopedia that is useful to the biologist, the chemist, the cosmetic scientist and to the clinician....this exellent current encyclopedia of the biology of pigment cells and their disorders should be on the bookshelf of anyone interested in this exciting field. -- Journal of Pigment Cell Research This is a comprehensive textbook on pigmentation. The editors, together with more than 100 contributors, integrated virtually all current knowledge of the pigmentary system into a volume encyclopedic in scope. --Archives of Dermatology This book is the first comprehensive treatise on pigmentation that combines its physiology in animals with its pathophysiology and clinical aspects in humans. The five editors have provided an opportunity for the leading investigators in pigmentation to show their stuff. The editors and authors have succeeded in presenting a thorough work. --The New England Journal of Medicine Ihe Pigmentary System: Physiology and Pathophysiology is a large, current, comprehensive and much needed text bringing together practically all aspects of normal pigment cell biology and ean extremely detailed presentation of most pigmentary disorders. The five editors, all well known in the pigment field, have brought together 104 other contributors to produce a pigment encyclopedia that is useful to the biologist, the chemist, the cosmetic scientist and to the clinician....this exellent current encyclopedia of the biology of pigment cells and their disorders should be on the bookshelf of anyone interested in this exciting field. -- Journal of Pigment Cell Research This is a comprehensive textbook on pigmentation. The editors, together with more than 100 contributors, integrated virtually all current knowledge of the pigmentary system into a volume encyclopedic in scope. --Archives of Dermatology Author InformationJames Nordlund is the Founding President of the PASPCR (Pan American Society for Pigment Cell Research), and a member of the Council of International Federations of Pigment Cell Societies. Tab Content 6Author Website:Countries AvailableAll regions |