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Th chapter d u th u f d m t r bb t n t x t and safety t t ng of substances u h drug , h m l , nd m d l d v th t can m t hum n f t . While non-clinical testing l b n f t animals with development of veterinary drug , th x m l nd r dur d r b d in th h t r r r nt those mm nl u d n r r h nd r gul t d non-clinical f t testing settings. Toxicity nd f t tud should lw be conducted in m l n w th l bl r gul t n , l w , policies, nd gu d l n w ll the r u r m nt f d by th facility's Institutional Animal Care nd U C mm tt (IACUC). D m t rabbits, Or t l gu un ulu , belonging t th rd r L g m r h nd the f m l L r d , are easily h u d nd h ndl d. R bb t r small r l t v t th r (m n g , d g , and m nk ) v lu t d n t x t nd f t studies, but l rg enough t l conduct ul r and d rm l irritation nd embryo-fetal v lu t n . Br d frequently u d n non-clinical tud include N w Z l nd Wh t (NZW) and Japanese lb n rabbits (3-5 kg r 6.6-11 lbs) nd th smaller, gm nt d Dutch Belted (0.9-1.8 kg; 2-4 lb ). Dutch B lt d rabbits r v d n dv nt g w th respect t th m unt of t t m t r l required ( r x m t l 40% less m r d with lb n r bb t ). Th l provide th b l t to t t f r t nt l ff t f drug nd h m l n m l n t development nd for t nt l u l f drug th t h v a r n t t b nd melanin n gm nt d r t n l th l um nd skin (S n , 2003). H m l n r bb t h v b n u d n developmental t x t tud , r m r l n Europe, nd v r l decades f nf rm t n exists d m n tr t ng n t nt nt r- nd intra-laboratory r r du t v data w th n r l v nt d ff r n compared w th reproductive d t in other r bb t br d (Viertel nd Tr b, 2002). Other breeds of rabbit r m t m u d u h as th Flemish G nt, Polish, nd Red Burgund to name a few (Gr tw hl et al., 1986; S l m n et l., 2007). H u ng nd f d requirements f r rabbits are w ll-kn wn (S l m n t l., 2007). S v r l characteristics h uld b n d r d wh n d gn ng toxicity nd f t tud nd t bl h ng r t r for r r t u rt v r nd endpoints. G tr nt t n l fl r f rabbits are l d ru t d, l d ng to d rrh nd poor h lth, nd common l b r t r r dur n lud step-wise l m t n t a f d (e.g., 120 gr m ) n -d l l m t d feeding r g m n. Coprophagia ( ng t n f f ) n rm l b h v r n rabbits. Ingestion f ft f l ll t x r t d in the rl morning essential b u b t r l syntheses of certain B vitamins n th cecum r x r t d t th time. Decreases n t v t nd f d consumption are m rt nt indicators f intolerance nd t x t . In ntr t, d r d food n um t n nd increased t v t , n lud ng ull ng hair fr m th r ruff to m k a n t, r n rm l h ng b rv d n r gn nt r bb t prior t delivery. N rm l rabbit urine n r mbl urul nt discharge; t often cloudy, v n paste-like, r ng ng fr m l ght ll w t deep r ng

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