Overview

This timely reference addresses the important aspects of the chemistry of the macrolides, azalides, and streptogramins; illustrates how the compounds are related; and details what structural changes are essential to achieve improved antibacterial activity and pharmacology. Explains the in vitro activity of the new agents and compounds them to other compounds used to treat outpatient infections. Presenting the proceeding of the first international conference on the topic, The New Macrolides, Azalides, and Streptogramins discusses the intracellular activity of azalides and new macrolides against Chlamydia, Staphyloccus aureus, Listeria monocytogenes, Legionella species, etc., demonstrates the potential uses of clarithromycin, roxithromycin, and azithromycin through animal models, reviews the safety of the newly developed macrolides and macrolide-like antibiotics and summarizes drug interactions. Describes the use of macrolides for treating respiratory infections, skin and skin structure infections, sexually transmitted diseases, and gastriontestinal infections, contains clinical trial findings of eight macrolides used to treat significant infections in children, considers the use of macrolides to manage difficult-to-treat conditions associated with HIV infection, revels the dramatic results of using clarithromycin in combination with minocycline to clear lepromatous lesions...and much more! The New Macrolides, Azalides, and Streptogramins serves as an excellent source for infectious disease specialists and pulmonologists, internists, pharmacologists and pharmacists, microbiologists, pediatricians, epidemiologists, and medicinal and biological chemists.

Full Product Details

Author:   Harold C. Neu ,  Lowell S. Young (Kuzell Institute for Arthritis and Infectious Diseases, San Francisco, California, USA) ,  Stephen H. Zinner
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Volume:   8
Dimensions:   Width: 21.60cm , Height: 1.70cm , Length: 27.90cm
Weight:   0.499kg
ISBN:  

9780824790387

ISBN 10:   0824790383
Pages:   256
Publication Date:   23 February 1993
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

Structure and In Vitro Activity Structure and Activity, Andre Bryskier, Constantin Agouridas, and J. R Chantot In Vitro Activity Against Gram-Positive and Gram-Negative Bacteria, Jacques Acar and Fred W. Goldstein In Vitro Activity Against Mycoplasma spp. and Intracellular Organisms, Geoffrey L. Ridgway Resistance to Macrolides, Azalides, and Streptogramins, Roland Leclercq and Patrice Courvalin Intracellular Activity, Paul M. Tulkens Animal Models, Pharmacology, Toxicity, and Drug Interactions Animal Models, Michael Barza Pharmacology, Hartmut Lode, M. Boeckh, Tom Schaberg, Klaus Borner, and Peter Koeppe Toxicity and Safety of Macrolides and Azalides, S. Ragnar Norrby Drug Interactions with Macrolide Antibiotics, Ron E. Polk Clinical Applications Clinical Use in Adults, Harold C. Neu Clinical Use in Pediatrics, Dieter Adam Changing Patterns of Infection in Neutropenic Patients: Implications for New Therapeutic and Prophylactic Approaches, Stephen H. Zinner Clinical Applications in the Treatment of HIV Infection, Merle A. Sande Otitis Media, Jerome O. Klein Sinusitis and Pharyngitis, Jerome O. Klein Bronchitis, Hiroyuki Kobayasbi Bacterial Pneumonia, Claude Carbon and Ethan Rubinstein Infections Due to Mycoplasma pneumoniae and Chlamydia pneumoniae, Margaret R. Hammerschlag Legionella Infection, Victor L. Yu The Use of Macrolides for the Treatment of Lyme Borreliosis, Benjamin J. Luft Skin and Skin Structure Infections, George A. Pankey Osteomyelitis, Layne O. Gentry Chancroid, Mark W. Tyndall, Egokin Malisa, J. O. Ndinya-Achola, Francis A. Plummer, and Allan R. Ronald Sexually Transmitted Chlamydial Infections, Gonorrhea, and Syphilis, H. Hunter Handsfield Gastrointestinal Infections, Including Campylobacter Helicobacter, and Cryptsporidium, Harold C. Neu Toxoplasma gondii, Fausto G. Araujo and Jack S. Remington Antimycobacterial Activity, Lowell S. Young, Clark B. Inderlied and Luis E. Bermudez Other Intracellular Infections, Including Brucellosis and Leptospirosis, Emilio Bouza Poster Rapporteurs' Summaries Review of Posters at the First International Conference on the Macrolides, Azalides, and Streptogramins In Vitro Activities, Takeshi Yokota Animal Models, Pharmacology, Toxicity, and Drug Interactions, Stephen H. Zinner Clinical Indications: Otitis Media, Sinusitis / Pharyngitis, Bronchitis, Pneumonia (Bacterial), Mycoplasma, Chlamydia pneumoniae, Legionella, and Lyme Disease, Ethan Rubinstein Clinical Indications: Skin and Soft Tissue Infections of Staphylococcal or Streptococcal Etiology, Lowell S. Young

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