Overview

Inf rt l t a mm n human health r bl m, ff t ng 10-15% of couples f r r du t v g . A common cause f nf rt l t d f t n germ ll production. In f m l , r t production and m nt n n results n nf rt l t , n Turn r syndrome nd premature v r n f lur . In men, m infertility are associated w th microdeletions of th Y hr m m , leading to r du t n f f w r no rm. D t severe rm r du t n r bl m , b l g l t rn t n b h v d thr ugh assisted reproductive t hn l g . Other m j r u of infertility r t d w th m t r bl m , such as bn rm l d v l m nt of the r r du t v tr t . In females, bn rm l t f th v r , oviducts, uterus, nd vagina are u f nf rt l t n endometriosis and polycystic v r n ndr m . Abn rm l t n Wollfian duct d v l m nt generally r ult n obstruction f rm fl w fr m the testes nd in t f br and ng n t l b l t r l b n f the v d f r n . D t th d nt f t n f a ub t f genes nv lv d in nf rt l t , ur und r t nd ng of th n rm l g n t r gul t n f hum n fertility remains l m t d. R nt advances and r r h n th field hold promise for b tud of r g n of nf rt l t and potential clinical l t n . N t v r n h the goal f b m ng a r nt, but f r th wh do, b ng un bl t n v a child n exquisitely painful reality. M n of u spend a rt n f our lives tt m t ng t v d un l nn d r gn n , and assume th t n w are ready t conceive, t w ll h n with l ttl d ff ult . We tend t th nk th t shifting gears fr m preventing r gn n t l nn ng conception and childbirth w ll r d n a relatively m th and orderly f h n. A f lur t conceive, th n, a major life stressor, which n wreak havoc n th rw well-adjusted couples. Even n t d ' society, we tend to um th t nd v du l n committed r l t n h h v th g l of procreation. W m n r ft n identified w th th r b l t t g v b rth. Both men and w m n r supposed t on th r g n t and g n r t n l l g . Failure by th r rt to fulf ll th r nd f th bargain n b devastating, humiliating, nd m t n ll destructive. Th continuing taboo g n t d u ng th ubj t f nf rt l t compounds these r t n . Even th ugh tr m nd u tr d h v b n m d n treating th r l t v l mm n condition, nf rt l t is typically n t nl d u d.

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