Overview

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

Full Product Details

Author:   Gregory Lloyd Blatch ,  Adrienne Lesley Edkins
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2015
Volume:   78
Dimensions:   Width: 15.50cm , Height: 1.60cm , Length: 23.50cm
Weight:   4.453kg
ISBN:  

9783319381497

ISBN 10:   3319381490
Pages:   276
Publication Date:   24 September 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Preface.- List of Contributors- About the Editors- GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG domain proteins: Nucleotide exchange factors for Hsp70 molecular chaperones.- Functions of the Hsp90-Binding FKBP Immunophilins.- Hsp70/Hsp90 organising protein (Hop): beyond interactions with chaperones and prion proteins.- Specification of Hsp70 function by Type I and Type II Hsp40.- Cdc37 as a Co-chaperone to Hsp90.- p23 and Aha1- UCS proteins: chaperones for myosin and co-chaperones for Hsp90.- Chaperonin - Co-chaperonin Interactions.- Co-chaperones of the mammalian endoplasmic reticulum.- The evolution and function of co-chaperones in mitochondria.- CHIP: a co-chaperone for degradation by the proteasome.- The role of HSP70 and its co-chaperones in protein misfolding, aggregation and disease.- Index

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