Overview
Hydrogen bond (H-bond) effects are known: it makes sea water liquid, joins cellulose microfibrils in trees, shapes DNA into genes and polypeptide chains into wool, hair, muscles or enzymes. Its true nature is less known and we may still wonder why O-H...O bond energies range from less than 1 to more than 30 kcal/mol without apparent reason. This H-bond puzzle is re-examined here from its very beginning and presented as an inclusive compilation of experimental H-bond energies and geometries.New concepts emerge from this analysis: new classes of systematically strong H-bonds (CAHBs and RAHBs: charge- and resonance-assisted H-bonds); full H-bond classification in six classes (the six chemical leitmotifs); and assessment of the covalent nature of strong H-bonds. This leads to three distinct but inter-consistent models able to rationalize the H-bond and predict its strength, based on classical VB theory, matching of donor-acceptor acid-base parameters (PA or pKa), or shape of the H-bond proton-transfer pathway. Applications survey a number of systems where strong H-bonds play an important functional role, namely drug-receptor binding, enzymatic catalysis, ion-transport through cell membranes, crystal design and molecular mechanisms of functional materials.
Full Product Details
Author: Gastone Gilli (Full Professor of Physical Chemistry, Director of the Centre for Structural Diffractometry, University of Ferrara, Italy) ,
Paola Gilli (Department of Chemistry, University of Ferrara, Italy)
Publisher: Oxford University Press
Imprint: Oxford University Press
Volume: 23
Dimensions:
Width: 16.30cm
, Height: 2.10cm
, Length: 24.10cm
Weight: 0.705kg
ISBN: 9780199558964
ISBN 10: 0199558965
Pages: 330
Publication Date: 25 June 2009
Audience:
College/higher education
,
Professional and scholarly
,
Undergraduate
,
Postgraduate, Research & Scholarly
Format: Hardback
Publisher's Status: Active
Availability: To order
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.
Reviews
<br> This book should be required reading for biochemists as well as for anyone who designs or interprets empirical models that need to reproduce systems where H-bonding is important. A valuable contribution to our understanding of H-bonds. The Gillis should be commended for the considerable time and effort they must have spent on this endeavor. --Journal of the American Chemical Society<p><br> A real contribution to the field. --Gautam R. Desiraju, University of Hyderabad<p><br>
<br> This book should be required reading for biochemists as well as for anyone who designs or interprets empirical models that need to reproduce systems where H-bonding is important. A valuable contribution to our understanding of H-bonds. The Gillis should be commended for the considerable time and effort they must have spent on this endeavor. --Journal of the American Chemical Society<br> A real contribution to the field. --Gautam R. Desiraju, University of Hyderabad<br>
A real contribution to the field. --Gautam R. Desiraju, University of Hyderabad<br>
A real contribution to the field. Gautam R. Desiraju, University of Hyderabad
Author Information
Gastone Gilli Full Professor of Physical Chemistry and Director of the Centre for Structural Diffractometry University of Ferrara, Italy Dr Paola Gilli Researcher of Physical Chemistry University of Ferrara, Italy
